{"id":"W4319068412","doi":"10.1200/jco.22.01990","title":"Pembrolizumab Plus Chemotherapy in Squamous Non–Small-Cell Lung Cancer: 5-Year Update of the Phase III KEYNOTE-407 Study","year":2023,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":512,"is_retracted":false,"has_abstract":true,"ca_institutions":"Kingston General Hospital","funders":"","keywords":"Pembrolizumab; Medicine; Clinical endpoint; Carboplatin; Internal medicine; Hazard ratio; Lung cancer; Placebo; Chemotherapy; Oncology; Population; Clinical trial; Phases of clinical research; Cancer; Surgery; Confidence interval; Pathology; Immunotherapy; Cisplatin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00384867,0.0001781545,0.001595297,0.0002134469,0.00004648927,0.000007423046,0.0004122942,0.00031144,0.000326031],"category_scores_gemma":[0.0003863527,0.0001104541,0.0006688491,0.0006602047,0.0002150175,0.000056328,0.00007812581,0.00104678,0.000006510775],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000361146,"about_ca_system_score_gemma":0.002912971,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003378019,"about_ca_topic_score_gemma":0.0004509936,"domain_scores_codex":[0.9958783,0.0004388987,0.002697741,0.0002254546,0.0004422045,0.0003173961],"domain_scores_gemma":[0.9965092,0.0009112374,0.001815203,0.0003577434,0.0002413687,0.0001652645],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.297943,0.01744928,0.4070747,0.0002650203,0.002040135,0.001470936,0.004679912,0.0003348507,0.008808617,0.00001293384,0.03226704,0.2276535],"study_design_scores_gemma":[0.3414296,0.0237136,0.5937942,0.0003069689,0.0007979144,0.0001147544,0.002188073,0.001554662,0.001579045,0.00005148828,0.03421496,0.0002547035],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884235,0.0007865348,0.00001704551,0.007465809,0.001791007,0.0007690691,0.000006747158,0.00001167652,0.0007286336],"genre_scores_gemma":[0.9927728,0.003327355,0.00008327101,0.002406358,0.000683244,0.00001438001,0.000001310964,0.00002919031,0.0006820938],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2273988,"threshold_uncertainty_score":0.5167485,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06809060181907818,"score_gpt":0.4589729620350002,"score_spread":0.390882360215922,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}