{"id":"W4319069458","doi":"10.1126/sciadv.add9109","title":"Epistasis between promoter activity and coding mutations shapes gene evolvability","year":2023,"lang":"en","type":"article","venue":"Science Advances","topic":"Evolution and Genetic Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Université Laval","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Gene; Promoter activity; Evolvability; Genetics; Biology; Coding region; Epistasis; Transcription (linguistics); Promoter; Computational biology; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006748752,0.0004877516,0.0005780289,0.0009168072,0.000278023,0.001022611,0.0004277356,0.0006949677,0.00192044],"category_scores_gemma":[0.002948004,0.0003731906,0.0003200544,0.0003866144,0.0007473793,0.0005345576,0.0009939839,0.0008136759,0.0003658163],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005923479,"about_ca_system_score_gemma":0.0003884449,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000539529,"about_ca_topic_score_gemma":0.00104421,"domain_scores_codex":[0.9993643,0.0001987321,0.00004174289,0.0001596911,0.0001516948,0.0000838827],"domain_scores_gemma":[0.9987364,0.0006027879,0.0002320451,0.0001438795,0.0001143194,0.0001705128],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003367165,0.0000644573,0.02928225,0.00007307543,0.000112277,0.0004067454,0.0001730843,0.01054455,0.9402126,0.004709741,0.0002329495,0.01385147],"study_design_scores_gemma":[0.0001305013,0.0007767337,0.5110886,0.00005169267,0.0003956881,0.003246217,0.0008256086,0.2539125,0.1948991,0.02868423,0.005681638,0.0003074881],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905269,0.0001329365,0.007014522,0.0001236319,0.000007246457,0.000008625841,0.00008999894,0.0001400432,0.001956132],"genre_scores_gemma":[0.9980239,0.00007581132,0.001405774,0.00003970167,0.000003739002,0.000008711988,0.00005374551,0.00005535288,0.000333405],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00192044,"threshold_uncertainty_score":0.006424487,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01657895987243366,"score_gpt":0.3158484485204591,"score_spread":0.2992694886480254,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}