{"id":"W4319072946","doi":"10.1261/rna.079273.122","title":"Spliceosome assembly and regulation: insights from analysis of highly reduced spliceosomes","year":2023,"lang":"en","type":"review","venue":"RNA","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; McGill University; University of Alberta; University of Northern British Columbia","funders":"","keywords":"Spliceosome; RNA splicing; Biology; Minor spliceosome; snRNP; Genetics; Splicing factor; Intron; Cell biology; Computational biology; RNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004585393,0.000604518,0.0008805093,0.001571282,0.0001527828,0.000719726,0.0005373173,0.000760109,0.0006385284],"category_scores_gemma":[0.0003163069,0.0003320698,0.0003498206,0.00125245,0.0005587474,0.0009061542,0.000498092,0.001178849,0.0008628277],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007604289,"about_ca_system_score_gemma":0.0005275666,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007229797,"about_ca_topic_score_gemma":0.0006784459,"domain_scores_codex":[0.9998753,0.00001404123,0.00001332009,0.00003817334,0.00004624185,0.00001285266],"domain_scores_gemma":[0.9998336,0.00006045183,0.00002802382,0.000009111312,0.00005262575,0.00001609024],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001631577,0.00006287028,0.0008702861,0.01680468,0.0001403398,0.0006386098,0.0001901794,0.002124511,0.112471,0.02005422,0.01042326,0.836057],"study_design_scores_gemma":[0.00001877066,0.0001606812,0.004877126,0.002004291,0.0001963262,0.004016807,0.0001162562,0.001141082,0.05230784,0.01013027,0.9249541,0.00007653343],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001610556,0.9936584,0.002024523,0.000270895,0.0001021176,0.000005328835,0.00005738848,0.00002197955,0.002248849],"genre_scores_gemma":[0.006116989,0.9910029,0.001467306,0.0002071254,0.00008871726,0.000009257033,0.000129726,0.000008906988,0.0009690586],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001571282,"threshold_uncertainty_score":0.005517364,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04208351698285673,"score_gpt":0.3413360960637205,"score_spread":0.2992525790808638,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}