{"id":"W4319072946","doi":"10.1261/rna.079273.122","title":"Spliceosome assembly and regulation: insights from analysis of highly reduced spliceosomes","year":2023,"lang":"en","type":"review","venue":"RNA","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; McGill University; University of Alberta; University of Northern British Columbia","funders":"","keywords":"Spliceosome; RNA splicing; Biology; Minor spliceosome; snRNP; Genetics; Splicing factor; Intron; Cell biology; Computational biology; RNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001272696,0.0002875149,0.001234851,0.0004487367,0.00006306698,0.00004069221,0.0002950216,0.0003758986,0.0000149251],"category_scores_gemma":[0.00009146682,0.0002375275,0.000486403,0.0009310755,0.0000665191,0.000004784687,0.0002268,0.0001525724,0.00002071545],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001892687,"about_ca_system_score_gemma":0.0001740398,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001872939,"about_ca_topic_score_gemma":0.0001013763,"domain_scores_codex":[0.9982539,0.0001304394,0.0005224151,0.0005987802,0.000260868,0.0002335348],"domain_scores_gemma":[0.9986736,0.00009360562,0.0003163649,0.0006848442,0.00008751268,0.0001440484],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006743288,0.00009749313,0.00006146611,0.006961029,0.0170764,0.00003856601,0.00005762605,0.00002521057,0.2901513,0.0006992132,0.001843582,0.6829206],"study_design_scores_gemma":[0.000340588,0.0002051477,0.001779078,0.003153623,0.00706367,0.000005184317,0.00002760613,0.000265016,0.007049352,0.0001289841,0.979136,0.000845726],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.08367115,0.9154776,0.00002628924,0.00001588255,0.00005883395,0.0002726179,0.0001370849,0.00001703501,0.0003234608],"genre_scores_gemma":[0.002885342,0.9910244,0.0001192723,0.00001181516,0.000280833,0.00003705965,0.001675146,0.0000490559,0.00391706],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9772924,"threshold_uncertainty_score":0.9686092,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04208351698285673,"score_gpt":0.3413360960637205,"score_spread":0.2992525790808638,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}