{"id":"W4319076978","doi":"10.1016/j.chom.2023.01.006","title":"Autophagy controls mucus secretion from intestinal goblet cells by alleviating ER stress","year":2023,"lang":"en","type":"article","venue":"Cell Host & Microbe","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":177,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"H2020 European Research Council; European Research Council; Vetenskapsrådet; Azrieli Foundation; Israel Science Foundation; European Crohn's and Colitis Organisation; Mizutani Foundation for Glycoscience; University of Texas Southwestern Medical Center","keywords":"Mucus; Secretion; Biology; Goblet cell; Autophagy; Inflammation; Unfolded protein response; Cell biology; Akkermansia muciniphila; Microbiology; Cystic fibrosis; Endoplasmic reticulum; Immunology; Gut flora; Epithelium; Endocrinology; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001914043,0.0002182452,0.0003264233,0.0002605327,0.0001949244,0.0004389903,0.00014598,0.0004067072,0.0005649918],"category_scores_gemma":[0.0001454614,0.0001377547,0.0002523948,0.000112577,0.0003410768,0.0003207863,0.000342858,0.0005054089,0.0002338681],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003408476,"about_ca_system_score_gemma":0.0002336265,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002882245,"about_ca_topic_score_gemma":0.0007071637,"domain_scores_codex":[0.9998512,0.00003057684,0.00001542282,0.00003196734,0.00002264769,0.0000482322],"domain_scores_gemma":[0.999861,0.00001139677,0.00004909086,0.00001303134,0.00001630726,0.00004907556],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001817911,0.00001365331,0.000253067,0.00002899727,0.000003542175,0.00002495703,0.000009246807,0.00002990767,0.998607,0.00008888147,0.0000429368,0.0007161039],"study_design_scores_gemma":[0.00007857798,0.0003811948,0.01946136,0.00002194867,0.00002771978,0.0002934906,0.00009180787,0.001371949,0.9741168,0.0002972267,0.003842705,0.00001508866],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941196,0.002623521,0.001597004,0.0003197022,0.00004198221,0.00001612673,0.0001314893,0.0001189135,0.001031752],"genre_scores_gemma":[0.9957411,0.001058931,0.001632517,0.0001132028,0.00001303773,0.0000209085,0.0001105172,0.00002256602,0.001287225],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005649918,"threshold_uncertainty_score":0.002473056,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006089994699399451,"score_gpt":0.2294891413160663,"score_spread":0.2233991466166669,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}