{"id":"W4319082476","doi":"10.1016/j.jaci.2022.12.419","title":"Efficacy And Safety Of Bradykinin B2 Receptor Inhibition With Oral PHVS416 In Treating Hereditary Angioedema Attacks: Results Of RAPIDe-1 Phase 2 Trial","year":2023,"lang":"en","type":"article","venue":"Journal of Allergy and Clinical Immunology","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ottawa Allergy Research Corporation; University of Ottawa; University of Alberta; Université de Montréal","funders":"","keywords":"Hereditary angioedema; Medicine; Bradykinin; Placebo; Angioedema; C1-inhibitor; Randomized controlled trial; Adverse effect; Visual analogue scale; Internal medicine; Antagonist; Clinical trial; Surgery; Receptor; Dermatology; Pathology; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002090269,0.001420397,0.002160357,0.0003394801,0.0003316022,0.001218682,0.0007233963,0.001626834,0.003135967],"category_scores_gemma":[0.001075908,0.0004335714,0.001817706,0.0002692449,0.0008300387,0.0009527063,0.0002147808,0.002890658,0.0006270694],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007358571,"about_ca_system_score_gemma":0.0006614343,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006582964,"about_ca_topic_score_gemma":0.0009946276,"domain_scores_codex":[0.9994106,0.000291634,0.00002861508,0.00008622854,0.00006194955,0.0001209709],"domain_scores_gemma":[0.9993439,0.0002413522,0.0001092274,0.00005223694,0.000047315,0.0002059347],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8269041,0.01400584,0.002694171,0.001348912,0.003309302,0.0002482557,0.0001724159,0.002055362,0.01954161,0.0006027745,0.004260163,0.124857],"study_design_scores_gemma":[0.8551201,0.1312878,0.007299397,0.00007378354,0.0007694895,0.0002444989,0.00004320621,0.0008267593,0.001893235,0.0003779765,0.002030096,0.00003354035],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.981231,0.01170535,0.0006411402,0.0008488529,0.0002617574,0.0008864522,0.001215509,0.0001429606,0.003066942],"genre_scores_gemma":[0.9846575,0.006044048,0.001172777,0.001364164,0.0003413044,0.00104584,0.001893676,0.00004262779,0.003438013],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003135967,"threshold_uncertainty_score":0.01105458,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04129731586687734,"score_gpt":0.3560950956476884,"score_spread":0.314797779780811,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}