{"id":"W4319082565","doi":"10.1016/j.jaci.2022.12.413","title":"Effectiveness, Safety, and Patient-Reported Outcomes (PROs) in Patients With Hereditary Angioedema (HAE) From the United States and Canada Treated With Lanadelumab: 24-Month Data From the EMPOWER Study","year":2023,"lang":"en","type":"article","venue":"Journal of Allergy and Clinical Immunology","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Hereditary angioedema; Medicine; Angioedema; Adverse effect; Observational study; Interim; Quality of life (healthcare); Internal medicine; Interim analysis; Randomized controlled trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003002737,0.0004580923,0.001145315,0.0004788632,0.000458335,0.001016105,0.0004552859,0.0005959067,0.000733223],"category_scores_gemma":[0.003866653,0.0001626221,0.002082447,0.001205002,0.0005416246,0.0005632883,0.0004858576,0.0009676588,0.00009205918],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002837339,"about_ca_system_score_gemma":0.002495823,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.08440708,"about_ca_topic_score_gemma":0.1673812,"domain_scores_codex":[0.998311,0.0005780288,0.000158646,0.0001908413,0.0004563873,0.0003050947],"domain_scores_gemma":[0.9955708,0.001305738,0.001626135,0.0001857507,0.0005699,0.0007416768],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0564524,0.001116054,0.8844185,0.0008771529,0.01244334,0.0001771282,0.0002949543,0.001229467,0.0005436505,0.0001607884,0.003509039,0.03877741],"study_design_scores_gemma":[0.003453073,0.002956466,0.9869687,0.0001412063,0.004251271,0.0001252127,0.0002185971,0.0005614122,0.000148443,0.00007172929,0.001058382,0.00004539568],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898111,0.006165245,0.00005384301,0.00021298,0.00002423448,0.00005164494,0.002732965,0.000007409471,0.0009406714],"genre_scores_gemma":[0.9950589,0.001636499,0.00008411844,0.0001923226,0.00003502351,0.00004377793,0.002734506,0.000002334441,0.0002125796],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9155929,"threshold_uncertainty_score":0.1678316,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02222058613298835,"score_gpt":0.2860815819409823,"score_spread":0.263860995807994,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}