{"id":"W4319082654","doi":"10.1016/j.jaci.2022.12.414","title":"Efficacy and Safety of Subcutaneous Garadacimab for the Prophylaxis of Hereditary Angioedema Attacks in Adults and Adolescent Patients with HAE: Results from a Multicenter, Placebo-Controlled Phase 3 Trial","year":2023,"lang":"en","type":"article","venue":"Journal of Allergy and Clinical Immunology","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"St. Michael's Hospital; University of Alberta; Ottawa Allergy Research Corporation; University of Ottawa","funders":"","keywords":"Hereditary angioedema; Medicine; Angioedema; Placebo; Dermatology; Multicenter study; Subcutaneous injection; Internal medicine; Randomized controlled trial; Pathology; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001163427,0.0009239158,0.002300413,0.0002892452,0.0003470391,0.0009360835,0.0006008827,0.001373608,0.002267811],"category_scores_gemma":[0.001107918,0.0003817191,0.00143911,0.0002716688,0.0009414994,0.0007768351,0.0001850722,0.00263965,0.000391124],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004082139,"about_ca_system_score_gemma":0.0005863601,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005379205,"about_ca_topic_score_gemma":0.001019905,"domain_scores_codex":[0.9996265,0.0001772564,0.00002286395,0.00006351673,0.00003636081,0.00007341892],"domain_scores_gemma":[0.9993211,0.0002159985,0.0001498078,0.00004111582,0.0000324209,0.0002395457],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9254561,0.009440352,0.00398658,0.0009592844,0.00255625,0.000155814,0.0001162427,0.000436584,0.008152972,0.0001793959,0.0009783068,0.04758208],"study_design_scores_gemma":[0.8945548,0.09002455,0.01220514,0.00006926426,0.0009953986,0.0001450273,0.00004161208,0.0004627429,0.0007696166,0.0001202219,0.0005915214,0.00002006599],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9887272,0.008848725,0.0002531892,0.000353242,0.0001751306,0.0005115484,0.000299608,0.00004744403,0.0007839053],"genre_scores_gemma":[0.9947857,0.002866793,0.0004225942,0.0004826342,0.0001923175,0.0004321613,0.0003276142,0.000009768429,0.0004804419],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002300413,"threshold_uncertainty_score":0.007586598,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02083636967747071,"score_gpt":0.3122501085314817,"score_spread":0.291413738854011,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}