{"id":"W4319082753","doi":"10.3390/vaccines11020340","title":"Development of Methamphetamine Conjugated Vaccine through Hapten Design: In Vitro and In Vivo Characterization","year":2023,"lang":"en","type":"article","venue":"Vaccines","topic":"Forensic Toxicology and Drug Analysis","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Victoria University","keywords":"Hapten; In vivo; In vitro; Conjugated system; Methamphetamine; Pharmacology; Medicine; Chemistry; Immunology; Biology; Antibody; Biotechnology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009198816,0.0001828596,0.0004444653,0.0004159267,0.00007379582,0.000005127571,0.0001147415,0.0002654399,0.0003987315],"category_scores_gemma":[0.0001214936,0.0001684339,0.00003460171,0.001069431,0.00003718911,0.0001329784,0.00007841922,0.0002399433,0.0000287015],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003205872,"about_ca_system_score_gemma":0.00006011729,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002307068,"about_ca_topic_score_gemma":0.0002081963,"domain_scores_codex":[0.9984441,0.0003071032,0.0005798405,0.0002837887,0.00007548908,0.0003096858],"domain_scores_gemma":[0.9992757,0.0003454012,0.0001531165,0.0001156134,0.00005420245,0.00005594948],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001411555,0.0001703801,0.02388496,0.00005542435,0.0001373326,0.00004059848,0.002511339,0.0005689289,0.9610003,0.00009550933,0.0002496355,0.009874102],"study_design_scores_gemma":[0.003201921,0.00004205347,0.1145678,0.00002269817,0.00007702325,0.000007193079,0.0002641626,0.01460601,0.8587277,0.0002840925,0.007970889,0.0002284543],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978669,0.0001649291,0.0004557738,0.0007738523,0.000226765,0.0002884862,0.00001990932,0.00006627248,0.0001371172],"genre_scores_gemma":[0.9965285,0.0003433846,0.002089776,0.0003738597,0.00003683366,0.00005405387,0.0001041115,0.00001602594,0.0004534628],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1022726,"threshold_uncertainty_score":0.6868536,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09258116481232248,"score_gpt":0.385010973651074,"score_spread":0.2924298088387515,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}