{"id":"W4319159752","doi":"10.1016/j.clim.2023.109250","title":"DNA methylation of ITGB2 contributes to allopurinol hypersensitivity","year":2023,"lang":"en","type":"article","venue":"Clinical Immunology","topic":"Drug-Induced Adverse Reactions","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"Chinese Academy of Medical Sciences Initiative for Innovative Medicine; Chiayi Chang Gung Memorial Hospital; Natural Science Foundation of Hunan Province; Chinese Academy of Meteorological Sciences; Ministry of Science and Technology of the People's Republic of China","keywords":"Allopurinol; Genotyping; Medicine; DNA methylation; Genotype; Methylation; Internal medicine; Biology; Genetics; DNA; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0006639021,0.0001067797,0.0005586278,0.0002378081,0.00003890606,0.000003116414,0.00007273327,0.0002722938,0.0000119341],"category_scores_gemma":[0.004020627,0.00009950221,0.0002004892,0.0005567695,0.0002247056,0.00004352576,0.0001174256,0.0003532598,0.001251008],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005562061,"about_ca_system_score_gemma":0.0001141808,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003563973,"about_ca_topic_score_gemma":0.00001281892,"domain_scores_codex":[0.9985741,0.0001840329,0.0005874283,0.0002805975,0.0001048345,0.0002689439],"domain_scores_gemma":[0.9976802,0.001465843,0.0001266589,0.0004205714,0.0002166182,0.00009006977],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001776168,0.0005286257,0.01059769,0.00002295042,0.0009678495,0.00009641345,0.0001094565,0.0000104795,0.7473002,0.003164141,0.0007313245,0.2362932],"study_design_scores_gemma":[0.001771134,0.0001904524,0.9139936,0.00005090029,0.0001944342,0.00002908021,0.0002903741,0.00006811481,0.03422383,0.0004010214,0.04868698,0.0001001004],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9820838,0.00005707049,0.0002103239,0.006901475,0.00110058,0.0003735481,0.00001299947,0.0001925918,0.009067625],"genre_scores_gemma":[0.9979769,0.0001397587,0.0002355922,0.0005135274,0.0001076833,0.00001582538,0.00004120178,0.00001729525,0.0009522266],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9033959,"threshold_uncertainty_score":0.9995266,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09539421477424183,"score_gpt":0.4174854557002559,"score_spread":0.322091240926014,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}