{"id":"W4319159752","doi":"10.1016/j.clim.2023.109250","title":"DNA methylation of ITGB2 contributes to allopurinol hypersensitivity","year":2023,"lang":"en","type":"article","venue":"Clinical Immunology","topic":"Drug-Induced Adverse Reactions","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"Chinese Academy of Medical Sciences Initiative for Innovative Medicine; Chiayi Chang Gung Memorial Hospital; Natural Science Foundation of Hunan Province; Chinese Academy of Meteorological Sciences; Ministry of Science and Technology of the People's Republic of China","keywords":"Allopurinol; Genotyping; Medicine; DNA methylation; Genotype; Methylation; Internal medicine; Biology; Genetics; DNA; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002459724,0.0002232677,0.0002047522,0.000274941,0.000146556,0.0003334361,0.0001528115,0.0003281438,0.002990714],"category_scores_gemma":[0.0005766829,0.0001379671,0.0002497497,0.0002137936,0.0001733877,0.0001278194,0.0002020254,0.0005102567,0.0002724329],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001795901,"about_ca_system_score_gemma":0.0001095631,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007022815,"about_ca_topic_score_gemma":0.0005269972,"domain_scores_codex":[0.9998024,0.00006346347,0.000009777335,0.00003421816,0.00003985591,0.0000503375],"domain_scores_gemma":[0.9997527,0.00006381535,0.00009853478,0.00002750019,0.00002066193,0.00003675373],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002447085,0.0002320127,0.2159725,0.0002100452,0.0004223307,0.002333577,0.000189369,0.0005521087,0.7115841,0.000745671,0.001354394,0.06395677],"study_design_scores_gemma":[0.0001360002,0.0006891756,0.9170826,0.00007181422,0.0003280175,0.006112245,0.0002363531,0.002116368,0.06495961,0.001138314,0.007112277,0.00001717153],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938359,0.002677093,0.0007347448,0.0003663696,0.00003435777,0.000009818755,0.000110524,0.00003747419,0.002193684],"genre_scores_gemma":[0.9987969,0.0003545203,0.0001418525,0.00008309371,0.00001705505,0.00000328662,0.00006422203,0.000005112203,0.0005339163],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002990714,"threshold_uncertainty_score":0.01000494,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09539421477424183,"score_gpt":0.4174854557002559,"score_spread":0.322091240926014,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}