{"id":"W4319161518","doi":"10.20944/preprints202302.0042.v1","title":"Targeting Matrix Exopolysaccharides to Disrupt &lt;em&gt;Pseudomonas aeruginosa&lt;/em&gt; Biofilms in Cystic Fibrosis","year":2023,"lang":"en","type":"preprint","venue":"Preprints.org","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Pseudomonas aeruginosa; Cystic fibrosis; Biofilm; Antibiotics; Microbiology; Extracellular matrix; Chronic infection; Antimicrobial; Biology; Medicine; Bacteria; Immunology; Internal medicine; Immune system; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000416016,0.0003480017,0.0004676652,0.0004879662,0.0001904013,0.0008479265,0.0002208097,0.0007114171,0.002301952],"category_scores_gemma":[0.0004462982,0.0001517522,0.0004132322,0.0002927035,0.0002623834,0.000575732,0.0003707181,0.0009895213,0.001384177],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003170399,"about_ca_system_score_gemma":0.0005272846,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003673781,"about_ca_topic_score_gemma":0.0005158969,"domain_scores_codex":[0.9998543,0.00002914921,0.00001196434,0.00001560423,0.00006597152,0.00002303666],"domain_scores_gemma":[0.9998785,0.00003163448,0.00001979507,0.000006942271,0.00003756154,0.00002557406],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005981104,0.0002154575,0.0009737572,0.0173732,0.0001796853,0.001768784,0.0005251238,0.001790314,0.3916358,0.0159596,0.03479236,0.5341878],"study_design_scores_gemma":[0.00007229829,0.0006643414,0.003371438,0.001777526,0.0001859106,0.002843418,0.0002349848,0.000757136,0.190677,0.004169852,0.7951874,0.00005876408],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.04443617,0.9151182,0.01235633,0.004873813,0.002848815,0.0001234723,0.000730837,0.000375123,0.01913726],"genre_scores_gemma":[0.1404402,0.8270237,0.01052862,0.001755063,0.0009146099,0.000136566,0.0008772982,0.0001150957,0.01820891],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.002301952,"threshold_uncertainty_score":0.007700801,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06500833237510532,"score_gpt":0.3647868991375073,"score_spread":0.2997785667624019,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}