{"id":"W4319162115","doi":"10.1101/2023.02.02.526879","title":"ATM phosphorylates the FATC domain of DNA-PK <sub>cs</sub> at threonine 4102 to promote non-homologous end joining","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Cumming School of Medicine, University of Calgary; American Cancer Society","keywords":"Phosphorylation; Non-homologous end joining; DNA damage; DNA repair; DNA; DNA-PKcs; Genome instability; Cell biology; Homologous recombination; Biology; DNA repair protein XRCC4; Molecular biology; Chemistry; Protein kinase A; Genetics; DNA mismatch repair","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008522166,0.0003439104,0.00008944473,0.0002053931,0.0001600005,0.0001997147,0.0001416943,0.0001677604,0.003741699],"category_scores_gemma":[0.00008044385,0.00009904179,0.0001661211,0.0001507112,0.0001427816,0.0001485184,0.000169817,0.0002777297,0.001473338],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002568876,"about_ca_system_score_gemma":0.0001361508,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003574542,"about_ca_topic_score_gemma":0.0004125312,"domain_scores_codex":[0.9999551,0.000005354407,0.00000246409,0.00001341285,0.00001114417,0.00001256271],"domain_scores_gemma":[0.9999728,0.000003545437,0.000008214164,0.000003280138,0.000003248299,0.000008921451],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001573466,0.00002646194,0.0006100071,0.00003023366,0.000005007819,0.0001199561,0.000008320396,0.000128719,0.9965904,0.0002857211,0.0002121455,0.001825882],"study_design_scores_gemma":[0.00001969554,0.00006469594,0.009784712,0.000003382562,0.000004153751,0.0004427192,0.00001357721,0.001432926,0.9844242,0.0001965764,0.00361039,0.0000030664],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890411,0.000746411,0.004225165,0.0001719008,0.0000649607,0.00002104806,0.0006444321,0.0001655184,0.004919433],"genre_scores_gemma":[0.9881071,0.0003792641,0.002063987,0.00003998283,0.00001852509,0.00001470066,0.00156745,0.00002526488,0.007783797],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003741699,"threshold_uncertainty_score":0.01251727,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01011540720630682,"score_gpt":0.2136217372805234,"score_spread":0.2035063300742166,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}