{"id":"W4319216299","doi":"10.1093/ecco-jcc/jjad020","title":"Declining Enrolment and Other Challenges in IBD Clinical Trials: Causes and Potential Solutions","year":2023,"lang":"en","type":"article","venue":"Journal of Crohn s and Colitis","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Population Health Research Institute; Western University","funders":"","keywords":"Clinical trial; Medicine; Protocol (science); Disease; Placebo; Clinical research; Patient recruitment; Crohn's disease; Intensive care medicine; Alternative medicine; Physical therapy; Family medicine; Internal medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.2866732,0.001440341,0.002238726,0.003427315,0.005511744,0.01121432,0.006690291,0.006928824,0.007858067],"category_scores_gemma":[0.4032681,0.001796152,0.002095515,0.005676008,0.00736034,0.008513029,0.008984036,0.0101723,0.001865968],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.01457354,"about_ca_system_score_gemma":0.03585453,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006333968,"about_ca_topic_score_gemma":0.00702939,"domain_scores_codex":[0.7051121,0.1732295,0.03809847,0.02090773,0.04907485,0.01357727],"domain_scores_gemma":[0.3177802,0.4628147,0.1225011,0.01941053,0.04559871,0.03189458],"domain_codex":null,"domain_gemma":"methods","domain_candidate":"methods","domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001260225,0.001071776,0.2068752,0.01141129,0.0007616827,0.002629094,0.023474,0.008186003,0.002974179,0.04143051,0.1270418,0.5728841],"study_design_scores_gemma":[0.001060715,0.004279657,0.3487698,0.02006156,0.0006311962,0.01024343,0.04005118,0.0342782,0.00390191,0.1533537,0.3820426,0.001326139],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.119652,0.03420471,0.06953465,0.7563707,0.003484714,0.002192607,0.0008430986,0.001356859,0.01236067],"genre_scores_gemma":[0.7189562,0.0204185,0.09701259,0.1416007,0.008140277,0.005585982,0.001411594,0.0008320227,0.006042145],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.7133268,"threshold_uncertainty_score":0.8796589,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1147339864046941,"score_gpt":0.3786928563995722,"score_spread":0.2639588699948781,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}