{"id":"W4319221979","doi":"10.1016/j.toxrep.2023.02.001","title":"Genetic and epigenetic instability induced by betel quid associated chemicals","year":2023,"lang":"en","type":"review","venue":"Toxicology Reports","topic":"Oral Health Pathology and Treatment","field":"Dentistry","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Ministry of Rural Affairs; Ministry of Science and Technology, Taiwan; University Grants Commission; Department of Biotechnology, Ministry of Science and Technology, India","keywords":"Areca; Carcinogen; Smokeless tobacco; Betel; Epigenetics; DNA damage; DNA repair; Cancer research; Genotoxicity; Tobacco smoke; Nicotine; Chemistry; Biology; Medicine; Pharmacology; Genetics; DNA; Gene; Internal medicine; Environmental health; Toxicity; Tobacco use","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000115021,0.0002503645,0.0003284183,0.000738158,0.0001536531,0.000380923,0.0002453772,0.0003601566,0.001248296],"category_scores_gemma":[0.0002313308,0.0001042848,0.0003239095,0.0004931514,0.0001500439,0.0002299505,0.0002143234,0.0002322234,0.0002361639],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003696571,"about_ca_system_score_gemma":0.0002227523,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007520861,"about_ca_topic_score_gemma":0.001399714,"domain_scores_codex":[0.9998946,0.00001517331,0.0000125957,0.00002274217,0.00003912619,0.00001574792],"domain_scores_gemma":[0.999898,0.00002620164,0.00004238956,0.000003191167,0.00002372883,0.00000650653],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00064778,0.0001252109,0.01932416,0.01625423,0.0004892219,0.005963183,0.0003737817,0.0008292837,0.3925893,0.003298863,0.008019169,0.5520859],"study_design_scores_gemma":[0.00005784122,0.001095099,0.182511,0.002663444,0.00143992,0.029624,0.000430862,0.001028304,0.2154803,0.004111011,0.5614849,0.00007331346],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.07526302,0.9157164,0.00159199,0.0006852164,0.000247216,0.00004363535,0.0005126854,0.0001028396,0.005836987],"genre_scores_gemma":[0.2348107,0.7525966,0.001741081,0.0007923515,0.0003216507,0.00005912399,0.0008671642,0.00001486973,0.008796588],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001248296,"threshold_uncertainty_score":0.004175961,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09896356465959635,"score_gpt":0.4052646024896205,"score_spread":0.3063010378300242,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}