{"id":"W4319232698","doi":"10.1101/2023.01.31.526523","title":"Anabolic phenotype in cartilage-specific Mitogen-inducible gene-6 knockout mice is independent of Transforming growth factor- <i>α</i>","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Cartilage; Transforming growth factor; Osteoarthritis; Epidermal growth factor receptor; TGF alpha; Osteoclast; Anabolism; SOX9; Chemistry; Knockout mouse; Growth factor; Endocrinology; Internal medicine; Cancer research; Cell biology; Receptor; Biology; Pathology; Medicine; Gene expression; Anatomy; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004314941,0.001485053,0.0006619857,0.001483353,0.0003647253,0.0008015442,0.0007121018,0.001160941,0.007967526],"category_scores_gemma":[0.0001966739,0.0007356387,0.000906273,0.000336306,0.0009146167,0.0004700999,0.0004454148,0.001966511,0.003267962],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003660619,"about_ca_system_score_gemma":0.000370557,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006761872,"about_ca_topic_score_gemma":0.001118078,"domain_scores_codex":[0.9993294,0.00006740855,0.0001031,0.0001522392,0.0002197999,0.0001280912],"domain_scores_gemma":[0.998838,0.00007931067,0.000555642,0.00008028276,0.00007741376,0.0003694553],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002269232,0.00007455031,0.0001724215,0.00005171726,0.00000758679,0.0001582346,0.00001687821,0.00003770571,0.9985207,0.0001497179,0.0000740918,0.0005095449],"study_design_scores_gemma":[0.000193081,0.00110182,0.009959015,0.00008115092,0.00008017398,0.002963719,0.0001286541,0.001401672,0.9746187,0.0001959027,0.009247853,0.00002831977],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9662225,0.001715678,0.01482335,0.000727419,0.0003160613,0.0002587681,0.007281433,0.001646757,0.007008008],"genre_scores_gemma":[0.9178023,0.002403605,0.01861166,0.0004587932,0.0001621426,0.0006130839,0.00620936,0.00106856,0.05267052],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007967526,"threshold_uncertainty_score":0.02665406,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02802691412446087,"score_gpt":0.2372430217298329,"score_spread":0.2092161076053721,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}