{"id":"W4319294019","doi":"10.1128/jvi.00009-23","title":"p38 Mitogen-Activated Protein Kinase Signaling Enhances Reovirus Replication by Facilitating Efficient Virus Entry, Capsid Uncoating, and Postuncoating Steps","year":2023,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Faculty of Medicine and Dentistry, University of Alberta; Canada Research Chairs; Canada Foundation for Innovation; University of Alberta; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Alberta Cancer Foundation; Cancer Research Society; Government of Canada; Alberta Health Services","keywords":"Oncolytic virus; Biology; MAPK/ERK pathway; Viral replication; KRAS; Viral entry; HRAS; Virology; Cancer research; Signal transduction; Virus; Cancer; Cell biology; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001956051,0.0004801944,0.0002133096,0.0002080616,0.0001396566,0.0003526961,0.0001290371,0.0001632529,0.001689944],"category_scores_gemma":[0.0001786463,0.00009359682,0.0002631079,0.00009121862,0.0001419235,0.0003291568,0.0001785064,0.000449529,0.0002985357],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002687846,"about_ca_system_score_gemma":0.000185597,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002476972,"about_ca_topic_score_gemma":0.0003496472,"domain_scores_codex":[0.9998593,0.00002864399,0.000008205356,0.00002512491,0.00003094767,0.00004767812],"domain_scores_gemma":[0.9999224,0.00002077792,0.00002357121,0.000007698595,0.000009205263,0.00001639195],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001443629,0.000045142,0.0004189328,0.00003112551,0.000002529464,0.00002293627,0.0000127281,0.00007497526,0.9960726,0.00007464743,0.00002803449,0.003072003],"study_design_scores_gemma":[0.00001004372,0.0005409954,0.006440048,0.000004978108,0.0000104028,0.0001737104,0.00002630729,0.0008723864,0.9901338,0.0000668592,0.001717048,0.000003466346],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919111,0.001591632,0.004759225,0.00007714953,0.00002134273,0.00004130754,0.0001938067,0.00008361862,0.001320895],"genre_scores_gemma":[0.996061,0.0005840838,0.002252614,0.00001325316,0.000006062327,0.00001972784,0.0001618111,0.000009483938,0.0008918645],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001689944,"threshold_uncertainty_score":0.005653441,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01804496029432676,"score_gpt":0.3063445887346239,"score_spread":0.2882996284402971,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}