{"id":"W4319294334","doi":"10.1371/journal.ppat.1011135","title":"Phenotypic effects of mutations observed in the neuraminidase of human origin H5N1 influenza A viruses","year":2023,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Health Canada","funders":"European Social Fund; Horizon 2020; Nederlandse Organisatie voor Toegepast Natuurwetenschappelijk Onderzoek; National Research Centre; Deutsche Forschungsgemeinschaft; European Commission; Deutsches Zentrum für Infektionsforschung; Nederlandse Organisatie voor Wetenschappelijk Onderzoek","keywords":"Influenza A virus subtype H5N1; Biology; Virology; Neuraminidase; Viral replication; Virulence; Virus; Influenza A virus; H5N1 genetic structure; Gene; Genetics; Coronavirus disease 2019 (COVID-19)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004028285,0.0001553546,0.0004213919,0.0003508547,0.00009970891,0.000008137242,0.0002009841,0.00006344825,0.00002118547],"category_scores_gemma":[0.002306634,0.0001090562,0.0001172647,0.001207713,0.0002324172,0.00006022204,0.00009531958,0.0002379458,0.00006367393],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003725439,"about_ca_system_score_gemma":0.00009330157,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001073629,"about_ca_topic_score_gemma":0.00006735315,"domain_scores_codex":[0.9981847,0.0002361766,0.0004515814,0.000209166,0.0005753056,0.0003430643],"domain_scores_gemma":[0.998052,0.00108944,0.0001242756,0.0004680034,0.0002061342,0.0000601186],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001198907,0.0005467407,0.1991004,0.001393902,0.0001846998,0.0002426182,0.00824085,0.00004302402,0.7886563,0.0005379962,0.0001910518,0.0007425549],"study_design_scores_gemma":[0.002409494,0.000705254,0.8853056,0.000426099,0.0002225778,0.000002549979,0.001075192,0.00026409,0.108793,0.000344931,0.0003133287,0.0001378879],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980388,0.0003224742,0.000001834611,0.0001015573,0.00003303268,0.0009589694,0.00006960879,0.00006215646,0.000411551],"genre_scores_gemma":[0.9990644,0.00003890397,0.00009338575,0.0004675778,0.00004841372,0.0001995279,0.0000172241,0.00002483226,0.00004566315],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6862052,"threshold_uncertainty_score":0.4447182,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2281771419307758,"score_gpt":0.4101008410574148,"score_spread":0.181923699126639,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}