{"id":"W4319295413","doi":"10.1128/aac.00749-22","title":"Repeated Emergence of Variant TetR Family Regulator, FarR, and Increased Resistance to Antimicrobial Unsaturated Fatty Acid among Clonal Complex 5 Methicillin-Resistant Staphylococcus aureus","year":2023,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Antimicrobial Resistance in Staphylococcus","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"TetR; Staphylococcus aureus; Efflux; Microbiology; Biology; Antimicrobial; Antibiotic resistance; Antibiotics; Methicillin-resistant Staphylococcus aureus; Regulator; Drug resistance; Gene; Genetics; Bacteria; Repressor; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002166202,0.0001842388,0.0002297143,0.0009755772,0.0002436088,0.0003193744,0.0001855278,0.0003203832,0.0009083235],"category_scores_gemma":[0.000745804,0.00009333692,0.0002005153,0.0006400634,0.0002423292,0.0001225205,0.0002896724,0.0002470766,0.0001458217],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002946536,"about_ca_system_score_gemma":0.0002294258,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00308931,"about_ca_topic_score_gemma":0.004188749,"domain_scores_codex":[0.999627,0.0000345924,0.00003214713,0.0001309089,0.0001159193,0.0000594044],"domain_scores_gemma":[0.9992535,0.0001470768,0.0002995809,0.00006974289,0.0001084156,0.0001217604],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003147272,0.0000370918,0.1488144,0.00006304649,0.00004320252,0.001164604,0.0003791447,0.00009476059,0.8410013,0.0001291148,0.0001161179,0.007842568],"study_design_scores_gemma":[0.00001168195,0.0004184587,0.8829181,0.00001622906,0.00006205252,0.008401372,0.0005776719,0.0006338218,0.1049702,0.00007681466,0.001886817,0.00002686719],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990836,0.0001635467,0.0003223223,0.00001258523,0.00000214132,0.000008998939,0.0001879471,0.000006706246,0.0002120859],"genre_scores_gemma":[0.998966,0.00006259893,0.0003819944,0.00001652437,0.000003461358,0.000004161028,0.0003516363,0.000004329616,0.0002092208],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00308931,"threshold_uncertainty_score":0.006142676,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02545526858012556,"score_gpt":0.2813763605898945,"score_spread":0.255921092009769,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}