{"id":"W4319298997","doi":"10.21203/rs.3.rs-2521252/v1","title":"The HUSH-SETDB1-MORC2 epigenetic repressor complex restricts herpesvirus infection in association with PML nuclear bodies","year":2023,"lang":"en","type":"preprint","venue":"Research Square","topic":"Cytomegalovirus and herpesvirus research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa","funders":"CHIST-ERA; Centre National de la Recherche Scientifique; Center for Virus Research, University of California, Irvine; Ligue Contre le Cancer; Institut National de la Santé et de la Recherche Médicale; Université Paris Diderot; Agence Nationale de la Recherche; University of Glasgow; Wellcome Trust","keywords":"Repressor; Epigenetics; Association (psychology); Biology; Virology; Genetics; Gene; Psychology; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003054861,0.0003079059,0.0004375921,0.0003658088,0.0005699011,0.001379323,0.0005583884,0.0005428603,0.006646311],"category_scores_gemma":[0.0005106433,0.0003746354,0.0004335844,0.0002767372,0.0005945269,0.0006059022,0.001055259,0.001247823,0.002299494],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001103899,"about_ca_system_score_gemma":0.0004670602,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001344742,"about_ca_topic_score_gemma":0.002171522,"domain_scores_codex":[0.9995522,0.00003182232,0.000017187,0.0001430119,0.0001513634,0.0001045186],"domain_scores_gemma":[0.9996923,0.00006032368,0.00005494289,0.00005820541,0.00002810614,0.0001060697],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001986414,0.0000125931,0.0006115375,0.00004994033,0.00001538149,0.00004330293,0.00002167399,0.0001007921,0.9960089,0.0005111547,0.0004268811,0.001999212],"study_design_scores_gemma":[0.00002597757,0.00003642834,0.0130214,0.000008051544,0.0000134411,0.000208758,0.00006337211,0.002067656,0.9775378,0.0002763759,0.006731897,0.000008902053],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9582565,0.006224786,0.0204938,0.001005587,0.0002853193,0.00004177319,0.002700335,0.0007598298,0.01023212],"genre_scores_gemma":[0.9821562,0.0006744973,0.005115155,0.0002211534,0.00005397278,0.0000264194,0.002681459,0.0002354511,0.008835725],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006646311,"threshold_uncertainty_score":0.02223408,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1322213884221518,"score_gpt":0.4157486441812541,"score_spread":0.2835272557591023,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}