{"id":"W4319299889","doi":"10.1093/femsml/uqad006","title":"<i>Mycobacterium tuberculosis</i> infection triggers epigenetic changes that are enriched in a type I IFN signature","year":2023,"lang":"en","type":"article","venue":"microLife","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; Institute of Infection and Immunity; University of Ottawa","funders":"National Sanitarium Association; Compute Canada; Canadian Institutes of Health Research; Hospital for Sick Children; University of Ottawa","keywords":"Chromatin; Biology; Epigenetics; Transcription factor; Gene; Chromatin immunoprecipitation; Mycobacterium tuberculosis; Interferon; Genetics; Gene expression; Promoter; Cell biology; Tuberculosis; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001276226,0.0001353694,0.0001284937,0.0001092949,0.00005332715,0.00002530899,0.00009801223,0.0002031403,0.0000278056],"category_scores_gemma":[0.00003070895,0.0001318385,0.000054928,0.0004064922,0.00002935269,0.000003280953,0.00005076852,0.0001047883,0.00006601686],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002896561,"about_ca_system_score_gemma":0.00004442493,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000732943,"about_ca_topic_score_gemma":0.0004940549,"domain_scores_codex":[0.9991965,0.00005389174,0.0001145848,0.0003065786,0.00008040496,0.0002480233],"domain_scores_gemma":[0.99955,0.000007171844,0.00006386512,0.0002726356,0.00005323713,0.00005302497],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004634218,0.00003163462,0.02505987,0.00002953082,0.00002406782,0.000003074413,0.00006675464,0.00009049721,0.962509,0.000002813113,0.01026157,0.001874854],"study_design_scores_gemma":[0.0006729922,0.0001369451,0.3619817,0.00003512036,0.00002348409,0.000009302496,0.0001118686,0.00004689467,0.4050022,0.0000288096,0.231617,0.0003337263],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957322,0.002652341,0.00004036654,0.0007662972,0.0003403627,0.0001765218,0.00002303101,0.00003492691,0.0002339541],"genre_scores_gemma":[0.9919391,0.005836218,0.00002290334,0.0006514207,0.0002336749,0.00006992037,0.0002317359,0.00002553706,0.0009895024],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5575068,"threshold_uncertainty_score":0.5376217,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01757639027658681,"score_gpt":0.2566038799873,"score_spread":0.2390274897107132,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}