{"id":"W4319303508","doi":"10.1371/journal.pgen.1010606","title":"Spinal cord extracts of amyotrophic lateral sclerosis spread TDP-43 pathology in cerebral organoids","year":2023,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"Canadian Institutes of Health Research; Fondation Brain Canada","keywords":"Astrogliosis; Amyotrophic lateral sclerosis; Biology; Spinal cord; Pathology; Organoid; Gliosis; Astrocyte; Induced pluripotent stem cell; Human brain; Cell biology; Neuroscience; Central nervous system; Medicine; Disease; Embryonic stem cell; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002484267,0.0002561542,0.0005790045,0.0004370784,0.000052072,0.00002142327,0.0002966311,0.0002816125,0.000486067],"category_scores_gemma":[0.0001790249,0.0002318283,0.000113933,0.001045697,0.0002640866,0.00006074972,0.0002843056,0.0005056993,0.000409356],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001259437,"about_ca_system_score_gemma":0.0001620712,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003876568,"about_ca_topic_score_gemma":0.00004077535,"domain_scores_codex":[0.9972481,0.000145531,0.0006124607,0.0004888328,0.0006938076,0.0008113057],"domain_scores_gemma":[0.9987693,0.00006174122,0.00011737,0.0005931989,0.0001954039,0.0002629736],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0009170828,0.0004146827,0.1812575,0.0002645252,0.00006621893,0.000450753,0.0002352805,0.00006271306,0.8089079,0.00004183603,0.0005180248,0.006863434],"study_design_scores_gemma":[0.001953928,0.002443424,0.9181489,0.0003572307,0.00005788872,0.00003619564,0.00003041952,0.002150888,0.07424048,0.0002327142,0.0001303184,0.0002175659],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973447,0.0002910639,0.000005977464,0.001309644,0.000152635,0.0005097236,0.00003070095,0.0001066831,0.0002488568],"genre_scores_gemma":[0.9974683,0.0006985106,0.0007339132,0.0001993271,0.0002183497,0.00003884226,0.00005928918,0.00007551914,0.0005079333],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7368914,"threshold_uncertainty_score":0.9453683,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09143679974532927,"score_gpt":0.3238944603614603,"score_spread":0.232457660616131,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}