{"id":"W4319304351","doi":"10.1155/2023/5336273","title":"CSF-Targeted Proteomics Indicate Amyloid-Beta Ratios in Patients with Alzheimer’s Dementia Spectrum","year":2023,"lang":"en","type":"article","venue":"International Journal of Alzheimer s Disease","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Genentech; Takeda Pharmaceutical Company; IXICO; H. Lundbeck A/S; Servier; Eisai; Northern California Institute for Research and Education; DoD Alzheimer's Disease Neuroimaging Initiative; Pfizer; Biogen; BioClinica; F. Hoffmann-La Roche; University of Southern California; Novartis Pharmaceuticals Corporation; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; GE Healthcare; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics; Johnson and Johnson; AbbVie; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Medicine; Dementia; BETA (programming language); Amyloid (mycology); Amyloid beta; Proteomics; Bioinformatics; Neuroscience; Internal medicine; Pathology; Disease; Psychology; Computer science; Biology; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003205699,0.0004392149,0.000331909,0.00137066,0.0003945786,0.0004210054,0.000175207,0.0003891354,0.001812604],"category_scores_gemma":[0.0009606241,0.0001404971,0.0001959116,0.0005491342,0.0001805461,0.000297965,0.0002213332,0.0002776156,0.0003674928],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000162024,"about_ca_system_score_gemma":0.0001188553,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007142295,"about_ca_topic_score_gemma":0.0006113753,"domain_scores_codex":[0.9998443,0.00002252185,0.00002903049,0.00004462574,0.00003446798,0.00002504108],"domain_scores_gemma":[0.9995622,0.00007809418,0.0001702857,0.00001634098,0.00009202997,0.00008110448],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009003644,0.0001164019,0.9801296,0.00004842479,0.00006997018,0.001341171,0.0001893668,0.00006081822,0.009413891,0.00003973844,0.0003058428,0.00738429],"study_design_scores_gemma":[0.00002146155,0.000309185,0.993284,0.00001273243,0.00005274143,0.004090154,0.0002232456,0.0001790008,0.001361559,0.0001323503,0.0003271324,0.00000648039],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987164,0.0004551688,0.00009058187,0.000025474,0.000009932692,0.000006490764,0.0001336879,0.00000890145,0.000553525],"genre_scores_gemma":[0.9993079,0.0001552011,0.0002013345,0.00003269844,0.0000136568,0.000006817465,0.0001216958,0.000001765484,0.0001588679],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001812604,"threshold_uncertainty_score":0.006063759,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02012746507009976,"score_gpt":0.3022134305595258,"score_spread":0.282085965489426,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}