{"id":"W4319316247","doi":"10.3390/cells12040524","title":"Generation of Conditional Knockout Alleles for PRUNE-1","year":2023,"lang":"en","type":"article","venue":"Cells","topic":"Mechanisms of cancer metastasis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children's Hospital Research Institute of Manitoba; University of Manitoba","funders":"Canadian Institutes of Health Research; Children's Hospital Research Institute of Manitoba","keywords":"Biology; Conditional gene knockout; Allele; Genetics; Neurodegeneration; Loss function; Null allele; Gene knockin; Transgene; Gene targeting; Cell biology; Gene; Disease; Phenotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001008253,0.00004884616,0.00006478228,0.00002394526,0.00002452885,0.000004255564,0.00006530758,0.00004812108,0.00004886687],"category_scores_gemma":[0.00002353205,0.00004972895,0.00005472919,0.00003644743,0.00001857847,0.000001173006,0.00002321104,0.0000119765,0.0000171191],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003013638,"about_ca_system_score_gemma":0.00003720597,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":9.287381e-7,"about_ca_topic_score_gemma":0.000003758777,"domain_scores_codex":[0.9996042,0.00001203769,0.00009992584,0.0001297083,0.00006663502,0.00008754384],"domain_scores_gemma":[0.9997399,0.000008334629,0.00004447877,0.00011853,0.00006559735,0.00002319173],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001162091,0.000008343483,0.000003517477,0.00001638134,0.00002056603,1.567889e-7,0.000007072739,0.0002521127,0.9417113,0.0006274247,0.05629073,0.001050781],"study_design_scores_gemma":[0.0002257835,0.00008633237,0.00004563028,0.000001638069,0.000008671212,3.829107e-7,0.00001196072,0.0002715805,0.9198311,0.000460846,0.07900573,0.00005034342],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.952652,0.0003041984,0.04506293,0.0002345476,0.0003932231,0.0003574307,0.0004447124,0.00001898974,0.0005319312],"genre_scores_gemma":[0.990931,0.000105817,0.00481283,0.0001333446,0.0003615913,0.00006575754,0.00142186,0.00001423379,0.002153617],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0402501,"threshold_uncertainty_score":0.2027888,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06374005960382827,"score_gpt":0.3078548844214289,"score_spread":0.2441148248176006,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}