{"id":"W4319316247","doi":"10.3390/cells12040524","title":"Generation of Conditional Knockout Alleles for PRUNE-1","year":2023,"lang":"en","type":"article","venue":"Cells","topic":"Mechanisms of cancer metastasis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children's Hospital Research Institute of Manitoba; University of Manitoba","funders":"Canadian Institutes of Health Research; Children's Hospital Research Institute of Manitoba","keywords":"Biology; Conditional gene knockout; Allele; Genetics; Neurodegeneration; Loss function; Null allele; Gene knockin; Transgene; Gene targeting; Cell biology; Gene; Disease; Phenotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007502943,0.001036116,0.0009035802,0.001365792,0.0006271878,0.0006054926,0.001424145,0.001335889,0.004308463],"category_scores_gemma":[0.000362238,0.000838523,0.0007461865,0.0005943805,0.0007660792,0.000570871,0.0008775293,0.002213741,0.002266473],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004791163,"about_ca_system_score_gemma":0.0005242005,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006414087,"about_ca_topic_score_gemma":0.001278493,"domain_scores_codex":[0.9991575,0.0000687541,0.0001297159,0.000254327,0.0002475742,0.0001420094],"domain_scores_gemma":[0.9991504,0.0001460641,0.0002663064,0.0001163387,0.00006798696,0.0002528235],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001384824,0.00008104908,0.0001658804,0.0001056561,0.00001761868,0.0002891726,0.00009396786,0.0001306889,0.9954627,0.001106698,0.0002884716,0.002119618],"study_design_scores_gemma":[0.0001384274,0.0003232502,0.002335572,0.00004822828,0.00008105714,0.001660316,0.00006410266,0.002150616,0.9726508,0.0002439825,0.02027173,0.00003199316],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8556496,0.004386803,0.1136052,0.0008001329,0.0006080372,0.001625396,0.01299999,0.00216173,0.008163077],"genre_scores_gemma":[0.8364724,0.005998889,0.08471762,0.0003951432,0.0001072386,0.002364983,0.01409348,0.001259387,0.05459088],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004308463,"threshold_uncertainty_score":0.01441324,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06374005960382827,"score_gpt":0.3078548844214289,"score_spread":0.2441148248176006,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}