{"id":"W4319316777","doi":"10.1136/jitc-2022-005691","title":"Tuned activation of MSLN-CAR T cells induces superior antitumor responses in ovarian cancer models","year":2023,"lang":"en","type":"article","venue":"Journal for ImmunoTherapy of Cancer","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"National Cancer Institute; Vetenskapsrådet; Karolinska Institutet; Cancerfonden; Barncancerfonden; Memorial Sloan-Kettering Cancer Center","keywords":"CD28; Mesothelin; Cancer research; T cell; Ovarian cancer; Flow cytometry; Tumor microenvironment; Chimeric antigen receptor; CD19; Immunotherapy; Cytotoxic T cell; Cancer; Biology; Immune system; Immunology; Medicine; In vitro; Antibody; Tumor cells; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001237397,0.0002738138,0.0002102077,0.0002326808,0.00006790313,0.0001959667,0.0001043642,0.000225512,0.0008107697],"category_scores_gemma":[0.00008283969,0.00006712283,0.0001429607,0.0001127679,0.0001567447,0.0001200346,0.0001306234,0.000530874,0.0001706261],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002025143,"about_ca_system_score_gemma":0.0001502194,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002112902,"about_ca_topic_score_gemma":0.0003419518,"domain_scores_codex":[0.9998894,0.0000140431,0.00001101906,0.00002215825,0.00002642584,0.0000370264],"domain_scores_gemma":[0.9999096,0.00001727467,0.00002716562,0.00001168621,0.000009478284,0.00002470064],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001907102,0.000120711,0.000236316,0.0000294427,0.000003153316,0.00002019767,0.00002139714,0.0001949431,0.9978024,0.00004668281,0.00003723717,0.001296697],"study_design_scores_gemma":[0.00003493089,0.001284575,0.001398214,0.000003615301,0.00001496681,0.00008958951,0.00001780942,0.0009326548,0.9952537,0.00001917769,0.0009490632,0.000001894025],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980845,0.0002780758,0.0009618684,0.00002582318,0.000007241422,0.00002476641,0.00009445852,0.00004611177,0.0004770776],"genre_scores_gemma":[0.9981846,0.0002029698,0.0006891434,0.00001799981,0.000006168275,0.00003370262,0.0001519991,0.00000829999,0.0007050532],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008107697,"threshold_uncertainty_score":0.002712309,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07222553027337288,"score_gpt":0.39572200909368,"score_spread":0.3234964788203072,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}