{"id":"W4319316995","doi":"10.3390/biology12020244","title":"Tau; One Protein, So Many Diseases","year":2023,"lang":"en","type":"review","venue":"Biology","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Tauopathy; Biology; Tau protein; Neuroscience; Gene isoform; Microtubule; Phenotype; Cytoskeleton; Intracellular; Cell biology; Alzheimer's disease; Cell; Disease; Pathology; Neurodegeneration; Genetics; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003133185,0.0007760737,0.0008957321,0.001204356,0.0005290121,0.001423977,0.0005490229,0.001264061,0.00666049],"category_scores_gemma":[0.0007064527,0.0001349117,0.0003062194,0.001473624,0.0006167875,0.001554572,0.0007432554,0.001778302,0.005299682],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004741882,"about_ca_system_score_gemma":0.00131632,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008399856,"about_ca_topic_score_gemma":0.001615094,"domain_scores_codex":[0.9997744,0.00004318761,0.00002621813,0.0000455822,0.00008769933,0.00002287257],"domain_scores_gemma":[0.9997694,0.00007428846,0.0000327406,0.00001049577,0.00007260467,0.000040451],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001112813,0.00005297943,0.0003015171,0.007171147,0.00008271014,0.0006298376,0.0001573572,0.0001010991,0.001655053,0.006949973,0.1799163,0.8028708],"study_design_scores_gemma":[0.000006099995,0.00001595181,0.0002076678,0.0007941597,0.00003084617,0.001287603,0.00003958023,0.00001584287,0.0001733259,0.002011756,0.9954106,0.000006446578],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002279249,0.9877403,0.0002484595,0.002743294,0.002264992,0.000005307287,0.00007428812,0.00003638673,0.006659008],"genre_scores_gemma":[0.002878158,0.9827905,0.0004181356,0.002862894,0.002418616,0.00001110664,0.0001580043,0.00001179139,0.008450741],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00666049,"threshold_uncertainty_score":0.02228159,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.149248893783811,"score_gpt":0.4312205678093516,"score_spread":0.2819716740255407,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}