{"id":"W4319316995","doi":"10.3390/biology12020244","title":"Tau; One Protein, So Many Diseases","year":2023,"lang":"en","type":"review","venue":"Biology","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Tauopathy; Biology; Tau protein; Neuroscience; Gene isoform; Microtubule; Phenotype; Cytoskeleton; Intracellular; Cell biology; Alzheimer's disease; Cell; Disease; Pathology; Neurodegeneration; Genetics; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00007762299,0.0003597983,0.001639537,0.0002370023,0.00009219624,0.00001666617,0.0001739952,0.0003461652,0.0004275872],"category_scores_gemma":[0.0001625625,0.0002407906,0.000558103,0.0002767757,0.0002372436,0.00001767119,0.0001656076,0.0002715422,0.005796602],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000117424,"about_ca_system_score_gemma":0.0011217,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005159525,"about_ca_topic_score_gemma":0.00000297919,"domain_scores_codex":[0.9981453,0.000208957,0.0003658956,0.0005444259,0.0001763419,0.0005590336],"domain_scores_gemma":[0.998644,0.0001192602,0.0001379114,0.0005391196,0.00006373784,0.0004959652],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000784424,0.0008036123,0.0002149621,0.024165,0.02689455,0.0009939028,0.000003396767,2.426627e-9,7.846638e-7,0.001155477,0.003425864,0.942264],"study_design_scores_gemma":[0.0005734888,0.0004870468,0.0001735129,0.007260132,0.005181319,0.00003194493,0.000002439608,3.505334e-7,9.088692e-7,0.0003140126,0.9857525,0.0002223416],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00001720426,0.9960087,0.000002458602,0.00009767159,0.00009717033,0.002525639,0.0007396388,0.0001951812,0.0003163155],"genre_scores_gemma":[0.00004759983,0.9935964,0.00004471772,0.00003307724,0.0005413911,0.001328839,0.003241131,0.00008230961,0.001084502],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9823266,"threshold_uncertainty_score":0.9949775,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.149248893783811,"score_gpt":0.4312205678093516,"score_spread":0.2819716740255407,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}