{"id":"W4319317554","doi":"10.3390/pharmaceutics15020527","title":"Insightful Improvement in the Design of Potent Uropathogenic E. coli FimH Antagonists","year":2023,"lang":"en","type":"article","venue":"Pharmaceutics","topic":"Escherichia coli research studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Ministero della Salute; Canadian Natural Resources Limited","keywords":"Bacterial adhesin; Escherichia coli; Microbiology; Chemistry; Bacteria; Biology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007459533,0.0001175056,0.0001160963,0.00005531878,0.00006841474,0.00001363595,0.0003146155,0.00004737894,0.000004042714],"category_scores_gemma":[0.0001305668,0.00008749174,0.00005453749,0.0003525435,0.00009906945,0.000002189497,0.0002475189,0.0001338496,0.00001259549],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001842476,"about_ca_system_score_gemma":0.00009453358,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001022488,"about_ca_topic_score_gemma":0.000008120547,"domain_scores_codex":[0.99883,0.0001987374,0.0002044269,0.0002009556,0.0002538921,0.0003119505],"domain_scores_gemma":[0.9995031,0.00005721546,0.00005623413,0.000263907,0.00007577272,0.0000437788],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008868382,0.0001045492,0.001462946,0.00004709061,0.00005326843,0.00002347512,0.0002638692,0.0005020511,0.9915019,0.00003445968,0.002385109,0.003532619],"study_design_scores_gemma":[0.001264729,0.0005522789,0.008960804,0.00001461018,0.00003972249,0.000006316722,0.0005943311,0.006663003,0.9150888,0.0001106378,0.06647409,0.0002306853],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954992,0.001494852,0.0007099317,0.0008686014,0.000148483,0.0007436185,0.00002888201,0.00001670624,0.0004897348],"genre_scores_gemma":[0.9940749,0.004790641,0.0002439153,0.000508034,0.0000815723,0.00009675706,0.00002272666,0.00001540791,0.0001660799],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07641309,"threshold_uncertainty_score":0.3567809,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07680680658396852,"score_gpt":0.3648013778750226,"score_spread":0.2879945712910541,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}