{"id":"W4319318721","doi":"10.3390/toxics11020151","title":"Long and Short Duration Exposures to the Selective Serotonin Reuptake Inhibitors (SSRIs) Fluoxetine, Paroxetine and Sertraline at Environmentally Relevant Concentrations Lead to Adverse Effects on Zebrafish Behaviour and Reproduction","year":2023,"lang":"en","type":"article","venue":"Toxics","topic":"Zebrafish Biomedical Research Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Canada; National Research Council Canada","funders":"Health Canada","keywords":"Paroxetine; Fluoxetine; Sertraline; Serotonin reuptake inhibitor; Zebrafish; Adverse effect; Premenstrual dysphoric disorder; Juvenile; Population; Antidepressant; Pharmacology; Toxicology; Biology; Serotonin; Physiology; Psychology; Internal medicine; Medicine; Endocrinology; Psychiatry; Ecology; Anxiety; Environmental health; Hormone","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009223774,0.0004011558,0.0002487758,0.0001583184,0.0002021175,0.000206291,0.0001996349,0.0004487277,0.002177431],"category_scores_gemma":[0.0001214872,0.0001962668,0.0004138105,0.00009694775,0.0003172153,0.0001696382,0.0003552545,0.000675156,0.000329272],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004907194,"about_ca_system_score_gemma":0.0005313921,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005042093,"about_ca_topic_score_gemma":0.01602276,"domain_scores_codex":[0.9998162,0.00001487861,0.00001715711,0.00005025358,0.00006512979,0.00003643596],"domain_scores_gemma":[0.9999079,0.00001322637,0.00003648701,0.000009560746,0.0000169369,0.00001597481],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009282091,0.00002091079,0.0005443059,0.00005032859,0.000009429508,0.00008570061,0.0000451032,0.00004143918,0.9979024,0.00003139685,0.0001111149,0.001065062],"study_design_scores_gemma":[0.00003425371,0.0036269,0.05948135,0.00005015393,0.00008413552,0.0004009918,0.0002085373,0.0005254154,0.930115,0.0001386079,0.005298587,0.00003605249],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919631,0.001097587,0.001815391,0.000223067,0.00006526262,0.00007046008,0.001519531,0.00009233968,0.003153119],"genre_scores_gemma":[0.9817433,0.002018769,0.003727171,0.0003653514,0.00001575428,0.0002463714,0.001502083,0.00002558833,0.01035549],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005042093,"threshold_uncertainty_score":0.0100255,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009422676093102404,"score_gpt":0.2699211206419353,"score_spread":0.2604984445488329,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}