{"id":"W4319318721","doi":"10.3390/toxics11020151","title":"Long and Short Duration Exposures to the Selective Serotonin Reuptake Inhibitors (SSRIs) Fluoxetine, Paroxetine and Sertraline at Environmentally Relevant Concentrations Lead to Adverse Effects on Zebrafish Behaviour and Reproduction","year":2023,"lang":"en","type":"article","venue":"Toxics","topic":"Zebrafish Biomedical Research Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Canada; National Research Council Canada","funders":"Health Canada","keywords":"Paroxetine; Fluoxetine; Sertraline; Serotonin reuptake inhibitor; Zebrafish; Adverse effect; Premenstrual dysphoric disorder; Juvenile; Population; Antidepressant; Pharmacology; Toxicology; Biology; Serotonin; Physiology; Psychology; Internal medicine; Medicine; Endocrinology; Psychiatry; Ecology; Anxiety; Environmental health; Hormone","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004030269,0.0001473036,0.0001072234,0.00005615325,0.0002643902,0.00003133811,0.00007790193,0.0001050125,0.000003963792],"category_scores_gemma":[0.0005386432,0.0001233586,0.00002142145,0.0002320121,0.0001177755,0.000009777697,0.0001964787,0.0001245195,0.00001642983],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004455613,"about_ca_system_score_gemma":0.00002657251,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001580218,"about_ca_topic_score_gemma":0.0003243714,"domain_scores_codex":[0.9986356,0.00008743811,0.0002090776,0.0005807144,0.0002343699,0.0002527768],"domain_scores_gemma":[0.9993079,0.00005530998,0.00003845194,0.0003255542,0.00004182237,0.0002309758],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000252591,0.00005466708,0.03292869,0.00001717591,0.0000256507,0.000005894291,0.0002640063,0.00004889341,0.950441,0.00001952382,0.009781273,0.006160617],"study_design_scores_gemma":[0.0004577579,0.0007450571,0.3326533,0.0000206487,0.00002034622,0.0000163352,0.000122569,0.0000817902,0.6597485,0.000009613889,0.005977696,0.0001463484],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9902537,0.00009248923,0.0001632431,0.007798098,0.00005101288,0.001539844,0.00003881711,0.00002971914,0.00003306807],"genre_scores_gemma":[0.9973118,0.0004130914,0.0003099708,0.0004240035,0.0002232547,0.0003952469,0.0002419555,0.00002128566,0.0006593334],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2997246,"threshold_uncertainty_score":0.5030417,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009422676093102404,"score_gpt":0.2699211206419353,"score_spread":0.2604984445488329,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}