{"id":"W4319321105","doi":"10.3389/fnins.2023.1126970","title":"Prader–Willi syndrome: Symptoms and topiramate response in light of genetics","year":2023,"lang":"en","type":"article","venue":"Frontiers in Neuroscience","topic":"Genetic Syndromes and Imprinting","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Topiramate; Impulsivity; Medicine; Psychiatry; Pharmacogenetics; Uniparental disomy; Pediatrics; Psychology; Epilepsy; Genetics; Chromosome; Genotype; Biology; Karyotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001849563,0.0003580236,0.0004030241,0.001056219,0.000388937,0.0002666179,0.0002641386,0.000377085,0.001742664],"category_scores_gemma":[0.001134743,0.0001341065,0.0002450964,0.0006091798,0.000364919,0.0003214163,0.0003378839,0.0003958898,0.0001825044],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002100597,"about_ca_system_score_gemma":0.0003469387,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001888693,"about_ca_topic_score_gemma":0.001960545,"domain_scores_codex":[0.9997919,0.00003318021,0.00003181872,0.00005189335,0.00004948865,0.0000417794],"domain_scores_gemma":[0.9996166,0.0001048034,0.0001295614,0.00001928597,0.00002986548,0.0000998715],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004285448,0.0001164176,0.8680898,0.00008104281,0.00005739922,0.1190203,0.0004008377,0.0001304589,0.003625232,0.0001618597,0.0003631093,0.007524926],"study_design_scores_gemma":[0.00002834151,0.0003467709,0.7396165,0.00002582442,0.00005024743,0.2576452,0.0003204095,0.0002474865,0.0005649325,0.0001437412,0.0009943598,0.00001617128],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970583,0.001015654,0.0001566789,0.00009221139,0.0000106913,0.00003244954,0.0002531125,0.000007685846,0.001373222],"genre_scores_gemma":[0.9988532,0.0003682221,0.0001633829,0.00004430452,0.00002464768,0.00001022179,0.0002007003,0.000002044455,0.0003332178],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001888693,"threshold_uncertainty_score":0.005829811,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008980407679292904,"score_gpt":0.239554890997614,"score_spread":0.2305744833183211,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}