{"id":"W4319321105","doi":"10.3389/fnins.2023.1126970","title":"Prader–Willi syndrome: Symptoms and topiramate response in light of genetics","year":2023,"lang":"en","type":"article","venue":"Frontiers in Neuroscience","topic":"Genetic Syndromes and Imprinting","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Topiramate; Impulsivity; Medicine; Psychiatry; Pharmacogenetics; Uniparental disomy; Pediatrics; Psychology; Epilepsy; Genetics; Chromosome; Genotype; Biology; Karyotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000389788,0.00009886199,0.0001432519,0.0001867486,0.00003032047,0.0000170886,0.0002302927,0.00007402446,7.617504e-7],"category_scores_gemma":[0.0002300119,0.000100846,0.000024471,0.000510384,0.0001402097,0.000004645538,0.000209742,0.00006708669,8.246555e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007639004,"about_ca_system_score_gemma":0.00004262208,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004160956,"about_ca_topic_score_gemma":0.000001957358,"domain_scores_codex":[0.9989054,0.00008418698,0.0002231667,0.0003754416,0.0001273566,0.0002844455],"domain_scores_gemma":[0.999615,0.00001126595,0.00005798541,0.0002510074,0.0000136862,0.00005112704],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00001259511,0.00002397464,0.4528757,0.00002892477,0.00000161047,0.00001197873,0.0001246821,0.0004218321,0.5437506,0.000008738988,0.0002658513,0.002473497],"study_design_scores_gemma":[0.0003226909,0.0004522297,0.9722926,0.00003004699,0.000001998982,0.00005590552,0.0001032557,0.002378057,0.01796032,0.00006057772,0.006214599,0.0001276946],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981928,0.0005051536,0.0003211761,0.0002448347,0.0005145809,0.0001358539,0.00000340583,0.000007630872,0.0000745501],"genre_scores_gemma":[0.9980166,0.0005749561,0.0009315282,0.0001034201,0.000008118658,0.000009142282,0.000001417131,0.0000109283,0.000343875],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5257903,"threshold_uncertainty_score":0.411238,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008980407679292904,"score_gpt":0.239554890997614,"score_spread":0.2305744833183211,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}