{"id":"W4319332861","doi":"10.5853/jos.2022.02880","title":"Replacing Alteplase with Tenecteplase: Is the Time Ripe?","year":2023,"lang":"en","type":"review","venue":"Journal of Stroke","topic":"Acute Ischemic Stroke Management","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; University of Calgary; Health Sciences Centre; Manitoba Health","funders":"","keywords":"Tenecteplase; Thrombolysis; Medicine; Clinical trial; Stroke (engine); Intensive care medicine; Fibrinolytic agent; Acute stroke; Tissue plasminogen activator; Internal medicine; Myocardial infarction; Engineering","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001423985,0.0006210941,0.002177243,0.001267652,0.0002286845,0.001299344,0.0009751943,0.001249514,0.003796711],"category_scores_gemma":[0.002116539,0.0002605245,0.00143042,0.001578617,0.0004277713,0.001678388,0.0004817969,0.001851747,0.001007713],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00057358,"about_ca_system_score_gemma":0.001556894,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001877496,"about_ca_topic_score_gemma":0.003762487,"domain_scores_codex":[0.9994897,0.0001489025,0.0001170639,0.00007217861,0.0001317439,0.00004027318],"domain_scores_gemma":[0.9994023,0.0003656829,0.0001105643,0.00001463534,0.0000854767,0.00002137213],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002545037,0.00003484428,0.0001106647,0.06942955,0.0005176353,0.00009791789,0.00008729021,0.0001655135,0.0009352043,0.002344935,0.01683283,0.9091891],"study_design_scores_gemma":[0.0003130937,0.0003647919,0.001932484,0.05489014,0.002130496,0.001617291,0.0002090746,0.0001172941,0.000803168,0.002754594,0.9348221,0.00004555584],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00009491058,0.9992086,0.00004286462,0.0002781194,0.0001209794,0.000004694185,0.00001156588,0.000002469984,0.0002357698],"genre_scores_gemma":[0.0009245425,0.9982343,0.0001745749,0.0003775927,0.00007347914,0.000009254912,0.00001844608,0.000001783985,0.0001860156],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003796711,"threshold_uncertainty_score":0.01270121,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03550846161706985,"score_gpt":0.3168721424387094,"score_spread":0.2813636808216395,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}