{"id":"W4319333837","doi":"10.1001/jama.2022.25029","title":"Four-Year Visual Outcomes in the Protocol W Randomized Trial of Intravitreous Aflibercept for Prevention of Vision-Threatening Complications of Diabetic Retinopathy","year":2023,"lang":"en","type":"article","venue":"JAMA","topic":"Retinal Diseases and Treatments","field":"Medicine","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Eye Institute","keywords":"Medicine; Aflibercept; Diabetic retinopathy; Visual acuity; Ophthalmology; Diabetes mellitus; Randomized controlled trial; Macular edema; Retinopathy; Clinical trial; Surgery; Bevacizumab; Internal medicine","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005275738,0.00008552914,0.0005508582,0.0001143646,0.00002279975,0.000005362238,0.00007357591,0.00004694824,0.00002071233],"category_scores_gemma":[0.0005500804,0.00005070326,0.0003098618,0.0002198866,0.00008414837,0.0000289771,0.00002035523,0.0000490428,0.000003260101],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001310561,"about_ca_system_score_gemma":0.00003756877,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000275611,"about_ca_topic_score_gemma":0.000001533424,"domain_scores_codex":[0.9988067,0.0001801841,0.0005472859,0.0001240737,0.0002336907,0.0001080501],"domain_scores_gemma":[0.9986699,0.0007008037,0.0002883626,0.0001971168,0.0001150282,0.00002882054],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9261548,0.003656891,0.03230891,0.001171366,0.00033383,0.00000966169,0.001075458,0.0000129188,0.002878595,0.0006806777,0.0002317019,0.03148523],"study_design_scores_gemma":[0.7256657,0.002436577,0.2669216,0.0003758267,0.0003224325,0.000001704219,0.0002071596,0.000595949,0.001045413,0.00234774,0.0000290865,0.00005080543],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.930283,0.000004756517,0.0000852533,0.0005597122,0.00002389202,0.06867087,0.00003064789,0.00001248974,0.000329455],"genre_scores_gemma":[0.9582595,0.00000441942,0.0004652058,0.00001461866,0.00002491906,0.04102278,0.00005733289,0.00001119155,0.0001399961],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2346127,"threshold_uncertainty_score":0.2067619,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03195225380985604,"score_gpt":0.3833723109497037,"score_spread":0.3514200571398476,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}