{"id":"W4319333915","doi":"10.1007/s00213-023-06320-y","title":"The abuse potential of lemborexant, a dual orexin receptor antagonist, according to the 8 factors of the Controlled Substances Act","year":2023,"lang":"en","type":"review","venue":"Psychopharmacology","topic":"Sleep and Wakefulness Research","field":"Neuroscience","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Altasciences (Canada); University of Toronto","funders":"Eisai","keywords":"Medicine; Orexin; Psychiatry; Adverse effect; Pharmacology; Internal medicine; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001459823,0.0004764955,0.001727642,0.0002482711,0.0006816305,0.00008783087,0.002797526,0.0002579741,0.0001686239],"category_scores_gemma":[0.001080686,0.0002000958,0.0009868322,0.001996065,0.0008932204,0.000075661,0.0003322362,0.00102095,0.00009911981],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007825556,"about_ca_system_score_gemma":0.0003984969,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005697938,"about_ca_topic_score_gemma":0.00005202655,"domain_scores_codex":[0.9938348,0.002624487,0.00117867,0.0006949554,0.0008464262,0.0008206473],"domain_scores_gemma":[0.9918746,0.006075669,0.0009673216,0.0008097569,0.0001385892,0.000134006],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.004817999,0.0005972479,0.0001616278,0.004231131,0.001932833,0.00006468307,0.001332446,0.00004552104,0.01985758,0.000750964,0.04317633,0.9230316],"study_design_scores_gemma":[0.002588984,0.0001476935,0.00002935254,0.0007424605,0.0006724043,0.00001621754,0.0003146607,0.00002240543,0.003918082,0.00006830466,0.9911868,0.0002926303],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.04170031,0.9335939,0.00001535234,0.001764921,0.01611874,0.005691106,0.0006022115,0.00007255536,0.0004408489],"genre_scores_gemma":[0.02410863,0.9735604,0.000002651564,0.0001513917,0.0005113897,0.0007108519,0.00000522956,0.00008159348,0.0008678694],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9480104,"threshold_uncertainty_score":0.815967,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1010455959362415,"score_gpt":0.4193789789726134,"score_spread":0.3183333830363719,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}