{"id":"W4319334451","doi":"10.1128/mbio.03384-22","title":"The ER Protein Translocation Channel Subunit Sbh1 Controls Virulence of Cryptococcus neoformans","year":2023,"lang":"en","type":"article","venue":"mBio","topic":"Fungal Infections and Studies","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health; Universität des Saarlandes; University of Bristol; Deutsche Forschungsgemeinschaft; Canada Foundation for Innovation; Burroughs Wellcome Fund","keywords":"Cryptococcus neoformans; Virulence; Protein subunit; Microbiology; Chromosomal translocation; Biology; Virology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002199845,0.0000631884,0.0001271747,0.00004736433,0.0001915386,0.000008500872,0.00004387763,0.00003406828,0.0000212028],"category_scores_gemma":[0.00006193535,0.00003927198,0.00005450309,0.0002660819,0.00008430867,0.00003606833,0.00001185124,0.00008453066,0.0001029302],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001431624,"about_ca_system_score_gemma":0.00002544869,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001087202,"about_ca_topic_score_gemma":0.00007536996,"domain_scores_codex":[0.9994801,0.00001779673,0.0001575563,0.00007910837,0.0001120181,0.0001534668],"domain_scores_gemma":[0.9996294,0.00005390495,0.00003793923,0.000150528,0.0001008148,0.00002734676],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00149149,0.0007885536,0.0159369,0.0009808618,0.0009630474,0.00003985473,0.01402584,0.0002793643,0.7799926,0.02505822,0.02672892,0.1337143],"study_design_scores_gemma":[0.009524631,0.003635543,0.3746402,0.001235278,0.0003468708,0.00003608997,0.0072234,0.01414708,0.3901403,0.005437276,0.192889,0.0007443161],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9859442,0.0005532062,0.0006228806,0.005576023,0.0002013711,0.001323681,0.00001584519,0.0001229557,0.005639829],"genre_scores_gemma":[0.9967227,0.0002200945,0.00001450834,0.00007094074,0.00006340604,0.000227625,0.000006257866,0.000007006258,0.002667489],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3898523,"threshold_uncertainty_score":0.1601465,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02362085237025697,"score_gpt":0.2767748265911539,"score_spread":0.253153974220897,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}