{"id":"W4319338186","doi":"10.1158/1078-0432.ccr-22-3032","title":"Impact of Genomic and Clinical Factors on Outcome of Children ≥18 Months of Age with Stage 3 Neuroblastoma with Unfavorable Histology and without <i>MYCN</i> Amplification: A Children's Oncology Group (COG) Report","year":2023,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Neuroblastoma Research and Treatments","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Division of Cancer Epidemiology and Genetics, National Cancer Institute; Hope Foundation; Ohio State University; National Cancer Institute; St. Baldrick's Foundation","keywords":"Neuroblastoma; Histology; Internal medicine; Univariate analysis; Oncology; Medicine; Multivariate analysis; Stage (stratigraphy); Cog; Confidence interval; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["sts"],"consensus_categories":[],"category_scores_codex":[0.002205248,0.0002826891,0.001516665,0.0004601161,0.00009864067,0.00001254456,0.0002482838,0.0002490426,0.0000815709],"category_scores_gemma":[0.0009764272,0.0001795659,0.0002164941,0.0006780676,0.002881713,0.00006866668,0.000253175,0.001193404,0.000006949487],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001545242,"about_ca_system_score_gemma":0.0009887535,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002861529,"about_ca_topic_score_gemma":0.0007463168,"domain_scores_codex":[0.9952593,0.00081781,0.001438115,0.0009553085,0.0008721355,0.0006573146],"domain_scores_gemma":[0.9954057,0.001997628,0.0006235785,0.000907579,0.0004302387,0.000635302],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0130728,0.001388613,0.9804019,0.0001186018,0.0009956685,0.0005163953,0.00005078096,0.00001356595,0.000917914,0.00002088529,0.0002974021,0.002205458],"study_design_scores_gemma":[0.007416772,0.03796015,0.9536475,0.0001212173,0.0001683034,0.0001788428,0.00003408562,0.00002508369,0.0002401316,0.00001601864,0.00006809268,0.0001238395],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972225,0.0001293973,0.000006465411,0.0002605674,0.00004173602,0.001784336,0.0002019387,0.00003669703,0.0003163381],"genre_scores_gemma":[0.9981112,0.000925657,0.00014639,0.00003293638,0.00006988307,0.00007112513,0.00008530962,0.00006298616,0.0004945269],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03657154,"threshold_uncertainty_score":0.9998319,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1945378628366252,"score_gpt":0.525337744972106,"score_spread":0.3307998821354807,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}