{"id":"W4319340680","doi":"10.1101/2023.02.07.527440","title":"The Dual Action of Human Antibodies Specific to <i>Plasmodium falciparum</i> PfRH5 and PfCyRPA: Blocking Invasion and Inactivating Extracellular Merozoites","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Malaria Research and Control","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Burnet Institute; Wellcome Trust; Canadian Institutes of Health Research; National Health and Medical Research Council; European Commission","keywords":"Basigin; Plasmodium falciparum; Epitope; Monoclonal antibody; Biology; Antibody; Extracellular; Cell biology; Immunology; Malaria; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002035232,0.000460692,0.0002418728,0.00009835023,0.00009134824,0.0001993424,0.0002509785,0.0003786576,0.0009565942],"category_scores_gemma":[0.0001460636,0.0001615932,0.0002640001,0.00005905427,0.000159368,0.0001548782,0.0001299886,0.0005466869,0.0002285821],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003094802,"about_ca_system_score_gemma":0.0001509174,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007520295,"about_ca_topic_score_gemma":0.0007888806,"domain_scores_codex":[0.9997965,0.00003821189,0.00001152739,0.00004601846,0.00003313701,0.00007465952],"domain_scores_gemma":[0.9999232,0.00002647835,0.00001531708,0.000008103429,0.00001032925,0.00001660386],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009085953,0.00001969397,0.00005070747,0.00002300478,0.000003498094,0.00001268482,0.000003357466,0.00003474179,0.9988814,0.00003730774,0.00003146712,0.0008113791],"study_design_scores_gemma":[0.00001917886,0.0003265848,0.001202956,0.000002912136,0.00001163578,0.0001255085,0.000003632308,0.0007912976,0.9966072,0.00000940535,0.0008979965,0.000001718119],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.987879,0.002336117,0.006319446,0.0001317261,0.00004162583,0.00005740219,0.000121571,0.0001331634,0.002980043],"genre_scores_gemma":[0.9918476,0.0005577942,0.005898917,0.0001062675,0.00002082448,0.00003879658,0.0001899692,0.00001890946,0.001320926],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009565942,"threshold_uncertainty_score":0.003200114,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04507813117455642,"score_gpt":0.2790043663412974,"score_spread":0.233926235166741,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}