{"id":"W4319345548","doi":"10.1016/j.cell.2023.01.005","title":"PIKFYVE inhibition mitigates disease in models of diverse forms of ALS","year":2023,"lang":"de","type":"article","venue":"Cell","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":98,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"National Institute of Neurological Disorders and Stroke; National Institute on Deafness and Other Communication Disorders; NIH Office of the Director; National Heart, Lung, and Blood Institute; Tau Consortium; Association for Frontotemporal Degeneration; National Institutes of Health; Target ALS; Discovery Institute; Bruno and Ilse Frick Foundation for Research on ALS; Harrington Discovery Institute, University Hospitals; John Douglas French Alzheimer's Foundation; University of Washington; Donald E. and Delia B. Baxter Foundation; National Human Genome Research Institute; University of Southern California; New York Stem Cell Foundation; Alzheimer's Drug Discovery Foundation; Muscular Dystrophy Association; Southern California Clinical and Translational Science Institute; California Institute for Regenerative Medicine; Milken Family Foundation; Ford Foundation; National Institute on Aging; Judith and Jean Pape Adams Charitable Foundation; U.S. Department of Defense","keywords":"Amyotrophic lateral sclerosis; Biology; TARDBP; SOD1; Disease; Mechanism (biology); C9orf72; Neuroscience; Autophagy; Protein aggregation; Ubiquitin; Genetics; Gene; Apoptosis; Medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003804839,0.0001684553,0.0004312097,0.0003402478,0.00002993511,0.000008170653,0.0001337539,0.0001306747,0.0003642508],"category_scores_gemma":[0.0001113203,0.0001417157,0.0001551682,0.0007334171,0.0002588365,0.0001864727,0.0002418067,0.0002313343,0.0004793913],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001069197,"about_ca_system_score_gemma":0.000171524,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000319752,"about_ca_topic_score_gemma":0.000008926873,"domain_scores_codex":[0.9979696,0.00008979901,0.0005469712,0.0002959172,0.0006239808,0.0004737539],"domain_scores_gemma":[0.9988828,0.0001258149,0.0001557334,0.0003667992,0.0001564868,0.000312367],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.003376736,0.002969871,0.1424059,0.01246878,0.0003314654,0.001318828,0.01129325,0.01936392,0.7900225,0.001616922,0.01129831,0.003533549],"study_design_scores_gemma":[0.01265637,0.001291923,0.445067,0.006283486,0.00059409,5.426546e-7,0.00187251,0.1495571,0.3495893,0.03199542,0.0003608829,0.0007313741],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952437,0.002346586,0.00001725077,0.0005411874,0.0001331032,0.0006144341,0.0002043594,0.00002458188,0.0008747715],"genre_scores_gemma":[0.9942579,0.004208453,0.00002560506,0.00004502147,0.0001046706,0.00002275273,0.0002113144,0.00002997184,0.001094357],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4404332,"threshold_uncertainty_score":0.6161765,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04474635295060772,"score_gpt":0.2901526269626132,"score_spread":0.2454062740120055,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}