{"id":"W4319347518","doi":"10.1038/s41585-023-00723-4","title":"Human in vitro spermatogenesis as a regenerative therapy — where do we stand?","year":2023,"lang":"en","type":"review","venue":"Nature Reviews Urology","topic":"Sperm and Testicular Function","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia Hospital; University of British Columbia","funders":"","keywords":"Spermatogenesis; Azoospermia; Germ cell; Male infertility; Biology; Stem cell; Cell biology; Mitosis; Sperm; Meiosis; Medicine; Genetics; Infertility; Gene; Andrology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["research_integrity"],"category_scores_codex":[0.0008312485,0.0007740102,0.004463456,0.0005985176,0.00008396194,0.00002402291,0.0002626282,0.002228936,0.0005369125],"category_scores_gemma":[0.0004525592,0.0005077425,0.001067037,0.001231926,0.00008749033,0.00004266437,0.00007323769,0.002483019,0.001054673],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002196545,"about_ca_system_score_gemma":0.0004164017,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001154346,"about_ca_topic_score_gemma":0.00002363809,"domain_scores_codex":[0.9959485,0.001092984,0.001212495,0.0009380021,0.0003115982,0.0004964522],"domain_scores_gemma":[0.9980331,0.0002200602,0.0005769472,0.0008959701,0.0001105728,0.0001633513],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006203193,0.000104483,0.00001120739,0.01841215,0.0002836474,0.0005881212,0.00004482573,7.348076e-8,0.00005752133,0.0004047202,0.009990509,0.9700407],"study_design_scores_gemma":[0.0007544745,0.0003114422,0.00000761223,0.01239812,0.001132666,0.001083443,0.000005132169,7.762495e-7,0.00001226382,0.0001022153,0.9838244,0.0003674813],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00001607174,0.9941672,0.000003299104,0.0006126711,0.0006955107,0.003405034,0.00003101166,0.0001186517,0.0009505404],"genre_scores_gemma":[0.000006268885,0.9959488,0.0001086584,0.0005427787,0.0009712136,0.0006186918,0.0001979571,0.0001573462,0.001448264],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9738339,"threshold_uncertainty_score":0.9998183,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06989563423091434,"score_gpt":0.3941948911600757,"score_spread":0.3242992569291613,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}