{"id":"W4319347518","doi":"10.1038/s41585-023-00723-4","title":"Human in vitro spermatogenesis as a regenerative therapy — where do we stand?","year":2023,"lang":"en","type":"review","venue":"Nature Reviews Urology","topic":"Sperm and Testicular Function","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia Hospital; University of British Columbia","funders":"","keywords":"Spermatogenesis; Azoospermia; Germ cell; Male infertility; Biology; Stem cell; Cell biology; Mitosis; Sperm; Meiosis; Medicine; Genetics; Infertility; Gene; Andrology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001981155,0.001035474,0.002813409,0.001983967,0.0003517021,0.002061895,0.001274397,0.001937933,0.003802305],"category_scores_gemma":[0.00157697,0.0003962716,0.0006516236,0.002201411,0.00112769,0.002279312,0.001074706,0.003607562,0.001971837],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009950185,"about_ca_system_score_gemma":0.002254372,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00192578,"about_ca_topic_score_gemma":0.004105693,"domain_scores_codex":[0.9996541,0.00008876482,0.00005237714,0.00005053207,0.0001200231,0.00003420244],"domain_scores_gemma":[0.9991006,0.0004759144,0.00009481898,0.00002281255,0.0002103354,0.0000956138],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001402064,0.0000575433,0.0001577152,0.01767012,0.0001205396,0.0001137562,0.00005111334,0.0003032488,0.0009772266,0.004983495,0.0511431,0.9242819],"study_design_scores_gemma":[0.00004748151,0.0001433661,0.0005642902,0.007257531,0.0002215726,0.0006236332,0.00008144503,0.0001073723,0.0002556531,0.002897473,0.9877725,0.00002758138],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00002201714,0.9989921,0.00005431347,0.0003983755,0.0002832266,0.000001415842,0.000008232289,0.000003498359,0.0002366788],"genre_scores_gemma":[0.0002665872,0.9985513,0.00009637449,0.0004978157,0.0003364808,0.000003151779,0.00001428504,0.000001245894,0.0002327436],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003802305,"threshold_uncertainty_score":0.01271993,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06989563423091434,"score_gpt":0.3941948911600757,"score_spread":0.3242992569291613,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}