{"id":"W4319432320","doi":"10.4049/jimmunol.206.supp.58.06","title":"Inhibition of JAK/STAT signaling sustain stem-like exhausted CD8+ T lymphocytes with enhanced antitumor effects","year":2021,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"","keywords":"Cytotoxic T cell; Adoptive cell transfer; CD8; T cell; Biology; Cancer research; JAK-STAT signaling pathway; Progenitor cell; Ex vivo; Interleukin 21; Cytokine; Immunology; Stem cell; Cell biology; In vivo; Signal transduction; Immune system; In vitro; Tyrosine kinase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008027771,0.0002552621,0.0001997693,0.0001338768,0.0000611568,0.0002287063,0.0001150967,0.0001384815,0.00148172],"category_scores_gemma":[0.00005619868,0.00006560537,0.0001460442,0.00008329166,0.0001062012,0.0001053717,0.00008803538,0.0006338061,0.0003371754],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001174154,"about_ca_system_score_gemma":0.0001701644,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001631702,"about_ca_topic_score_gemma":0.0003526561,"domain_scores_codex":[0.9999256,0.000008724178,0.000008317576,0.00001021654,0.00002199083,0.00002512332],"domain_scores_gemma":[0.999953,0.00000904787,0.00001098742,0.000004201635,0.000005435641,0.00001727657],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003568912,0.0001018301,0.0001315786,0.00005310466,0.000006169105,0.00001595533,0.000006606061,0.000244066,0.996675,0.00005073351,0.00009773395,0.0022602],"study_design_scores_gemma":[0.00006417659,0.001042784,0.001649267,0.000007333932,0.00002225587,0.00006752274,0.00001137949,0.001950281,0.99313,0.00004652078,0.002005312,0.000003171557],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951825,0.001343365,0.001469629,0.00008648331,0.00005130895,0.00003329668,0.0005395823,0.0001003046,0.001193631],"genre_scores_gemma":[0.9962912,0.000464568,0.0008710746,0.00006129932,0.00001146028,0.00003810237,0.0005898009,0.00001361135,0.001659023],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00148172,"threshold_uncertainty_score":0.004956841,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01298701227230628,"score_gpt":0.2742844501923555,"score_spread":0.2612974379200492,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}