{"id":"W4319438271","doi":"10.1038/s41531-023-00445-9","title":"Alterations in the LRRK2-Rab pathway in urinary extracellular vesicles as Parkinson’s disease and pharmacodynamic biomarkers","year":2023,"lang":"en","type":"article","venue":"npj Parkinson s Disease","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Atuka (Canada)","funders":"Centre hospitalier régional universitaire de Lille; Institut National de la Santé et de la Recherche Médicale; Michael J. Fox Foundation for Parkinson's Research","keywords":"LRRK2; Rab; Biology; Internal medicine; Pharmacology; Medicine; Cell biology; Parkinson's disease; GTPase; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007325337,0.0003792678,0.0005396128,0.0006961451,0.0001776272,0.0007370647,0.0001636832,0.000438079,0.0005698288],"category_scores_gemma":[0.0006060443,0.000153616,0.000347363,0.000476616,0.0003204864,0.0004143987,0.0003014806,0.0003678079,0.0001004564],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003036336,"about_ca_system_score_gemma":0.0002271165,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005511656,"about_ca_topic_score_gemma":0.000731288,"domain_scores_codex":[0.9996171,0.0001743534,0.00002829596,0.00006557736,0.00008188833,0.00003288273],"domain_scores_gemma":[0.9997254,0.00006068499,0.0001124558,0.00002449418,0.00004403619,0.00003283653],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.005776333,0.0003406896,0.155375,0.0009583486,0.0007112062,0.001650975,0.0002155354,0.001113449,0.7524235,0.0005226598,0.0004646039,0.0804476],"study_design_scores_gemma":[0.0001021817,0.004318749,0.5566255,0.0001104395,0.000580116,0.005282696,0.0003137449,0.006110802,0.4188981,0.0008538977,0.006750115,0.00005366918],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9792839,0.01461567,0.00414572,0.0001414587,0.00002806139,0.00005473501,0.0004520132,0.00008858379,0.001189913],"genre_scores_gemma":[0.9949083,0.00186678,0.002227171,0.000092996,0.00001309621,0.00003384055,0.0002815839,0.00001427719,0.0005618886],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007370647,"threshold_uncertainty_score":0.003874123,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0128835945991143,"score_gpt":0.2527305146125082,"score_spread":0.2398469200133939,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}