{"id":"W4319442566","doi":"10.1186/s13195-023-01178-w","title":"Initial levels of β-amyloid and tau deposition have distinct effects on longitudinal tau accumulation in Alzheimer’s disease","year":2023,"lang":"en","type":"article","venue":"Alzheimer s Research & Therapy","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; H. Lundbeck A/S; Servier; Eisai; Genentech; IXICO; National Natural Science Foundation of China; Pfizer; Novartis Pharmaceuticals Corporation; F. Hoffmann-La Roche; Shenzhen Bay Laboratory; Biogen; Eli Lilly and Company; Bristol-Myers Squibb; BioClinica; U.S. Department of Defense; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics; National Institute on Aging; Alzheimer's Association","keywords":"Entorhinal cortex; Psychology; Temporal lobe; Alzheimer's disease; Internal medicine; Neurodegeneration; Apolipoprotein E; Temporal cortex; Tau pathology; Senile plaques; Neuroscience; Longitudinal study; Disease; Oncology; Hippocampus; Medicine; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001023228,0.0003498881,0.0005236487,0.00106977,0.0002788363,0.00007562136,0.000197916,0.0001456816,0.0001320435],"category_scores_gemma":[0.0002472987,0.0002923421,0.0001662036,0.001101347,0.0004159777,0.0002915318,0.0001455724,0.0005594647,0.0001499207],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009282043,"about_ca_system_score_gemma":0.0004352968,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006336697,"about_ca_topic_score_gemma":0.00006884709,"domain_scores_codex":[0.9953409,0.0007398485,0.0004445082,0.0007431447,0.001736334,0.0009953073],"domain_scores_gemma":[0.9969878,0.00111244,0.00009086545,0.0006144479,0.0003621084,0.0008323553],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01757496,0.002270107,0.6766976,0.0001709105,0.01336632,0.003229191,0.0006858518,0.00004564808,0.002238534,0.0002667418,0.001183246,0.2822709],"study_design_scores_gemma":[0.006107599,0.0018628,0.9722422,0.0003321883,0.0003993237,0.00001157466,0.00007733814,0.001524929,0.01612919,0.001016471,0.00006032646,0.000236029],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9724884,0.02292283,0.00002047005,0.00120364,0.00007243198,0.00268533,0.0001304564,0.00009883503,0.0003776053],"genre_scores_gemma":[0.9975275,0.001270359,0.00004492002,0.0000774519,0.0002325229,0.0004272902,0.000326278,0.00007612002,0.00001759108],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2955447,"threshold_uncertainty_score":0.9999529,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2306875964443708,"score_gpt":0.4601775724755198,"score_spread":0.2294899760311491,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}