{"id":"W4319454754","doi":"10.1186/s40168-022-01454-1","title":"Ultra-sensitive isotope probing to quantify activity and substrate assimilation in microbiomes","year":2023,"lang":"en","type":"article","venue":"Microbiome","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Institute of General Medical Sciences; Novo Nordisk; Novo Nordisk Fonden; Canada Foundation for Innovation; U.S. Department of Energy; Government of Alberta; National Institute of Food and Agriculture; National Institutes of Health; Canada First Research Excellence Fund; Natural Sciences and Engineering Research Council of Canada; U.S. Department of Agriculture; University of Calgary; Foundation for Food and Agriculture Research; National Science Foundation","keywords":"Microbiome; Biology; Stable-isotope probing; Microbial ecology; Biogeochemical cycle; Assimilation (phonology); Metagenomics; Ecology; Evolutionary biology; Bacteria; Bioinformatics; Genetics; Microorganism; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003056942,0.0001960082,0.0002024356,0.0002871297,0.0001042911,0.00004943478,0.00009776185,0.0001857139,0.000005857562],"category_scores_gemma":[0.00002102751,0.0002047653,0.0000469414,0.0005642416,0.00006290113,0.000009312702,0.00008600827,0.0001148116,0.00009451387],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003982102,"about_ca_system_score_gemma":0.00007454467,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000116972,"about_ca_topic_score_gemma":0.0004399911,"domain_scores_codex":[0.9987043,0.00007541532,0.0002093947,0.0005215664,0.00004314898,0.0004462225],"domain_scores_gemma":[0.9995602,0.00001541115,0.0000627698,0.0002154808,0.00004964238,0.00009654342],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007429383,0.00003677467,0.002156032,0.00005203326,0.00001509768,0.000009678945,0.0004457262,0.00002273271,0.9948637,0.000007722476,0.001492272,0.0008238644],"study_design_scores_gemma":[0.0004521162,0.0001069438,0.1769548,0.00004601053,0.000005095948,0.00003117758,0.0001253007,0.00001396199,0.8171219,0.00000565405,0.004899826,0.0002372398],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979955,0.00006889908,0.0001564331,0.0008937057,0.0001313272,0.0004834524,0.0001053385,0.00003857519,0.0001267928],"genre_scores_gemma":[0.9983287,0.0001045889,0.0002771018,0.000345593,0.00005768639,0.00001638954,0.0002630418,0.0000292456,0.0005776341],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1777419,"threshold_uncertainty_score":0.8350088,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01887616543533658,"score_gpt":0.2858000551160053,"score_spread":0.2669238896806687,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}