{"id":"W4319457090","doi":"10.1056/nejmoa2209760","title":"Early Treatment with Pegylated Interferon Lambda for Covid-19","year":2023,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":174,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Toronto Liver Centre; Sunnybrook Health Science Centre; University Health Network; University of Toronto; Toronto East General Hospital; York University; McMaster University; Impact","funders":"University of Toronto; Erasmus Universiteit Rotterdam; Monash University; York University; Rainwater Charitable Foundation; Pontifícia Universidade Católica de Minas Gerais; National Institute of Allergy and Infectious Diseases; McMaster University; Bill and Melinda Gates Foundation; U.S. Department of Veterans Affairs","keywords":"Pegylated interferon; Coronavirus disease 2019 (COVID-19); Virology; Medicine; 2019-20 coronavirus outbreak; Interferon; Internal medicine; Ribavirin; Virus; Chronic hepatitis; Infectious disease (medical specialty); Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001378549,0.0004165392,0.0009136712,0.000200337,0.0001611959,0.0003940657,0.0003363656,0.0006960058,0.002398401],"category_scores_gemma":[0.001270349,0.0001623821,0.0008798867,0.0001271818,0.000446188,0.0002525005,0.0002931575,0.0008975579,0.0002188856],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004137416,"about_ca_system_score_gemma":0.0006591819,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004101379,"about_ca_topic_score_gemma":0.0005902917,"domain_scores_codex":[0.9995391,0.0002507503,0.00003841662,0.00007286941,0.00004220005,0.00005677393],"domain_scores_gemma":[0.9993704,0.0002030957,0.0002360737,0.00002624262,0.00002803539,0.0001361708],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7168285,0.009709154,0.01160909,0.003609644,0.001790153,0.0001852547,0.0001405839,0.001642062,0.01844663,0.000440006,0.001313202,0.2342857],"study_design_scores_gemma":[0.6483251,0.3107589,0.02776623,0.0006678281,0.001044415,0.0003780714,0.00008140724,0.00185617,0.004166493,0.0004602008,0.004465567,0.00002961219],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9873684,0.008144022,0.0009833272,0.0005963469,0.0002426695,0.001403092,0.0001504819,0.00005458493,0.001056968],"genre_scores_gemma":[0.9960562,0.001298008,0.000887687,0.000543009,0.0001032436,0.000684798,0.0001224934,0.0000032698,0.0003014014],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002398401,"threshold_uncertainty_score":0.008023441,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0778326619133602,"score_gpt":0.386193799023987,"score_spread":0.3083611371106268,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}