{"id":"W4319457605","doi":"10.1101/2023.02.07.23285520","title":"Loss of Y is associated with multi-omic changes in immune cells from Alzheimer’s disease patients","year":2023,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Brain Institute; Occupational Cancer Research Centre; University of Toronto; University Health Network","funders":"European Regional Development Fund; Vetenskapsrådet; Hjärt-Lungfonden; Cancerfonden; European Commission; Fundacja na rzecz Nauki Polskiej; Alzheimerfonden; Hjärnfonden","keywords":"Epigenetics; DNA methylation; Immune system; Transcriptome; Disease; Gene; Biology; Pathogenesis; Methylation; Immunology; Immune Dysfunction; Omics; Genetics; Gene expression; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001378598,0.0002267271,0.0003119715,0.0006148955,0.0002669557,0.0004006901,0.0001045562,0.0002795897,0.002159627],"category_scores_gemma":[0.0003645018,0.00009105333,0.0002461779,0.0003645141,0.0001562455,0.0001122966,0.0003373961,0.0002596821,0.0002898183],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000114962,"about_ca_system_score_gemma":0.00006423042,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00069398,"about_ca_topic_score_gemma":0.0005707798,"domain_scores_codex":[0.9998492,0.00001892341,0.00001850279,0.00005008109,0.00003041775,0.0000328582],"domain_scores_gemma":[0.9998395,0.00001711408,0.0000801209,0.00001568262,0.00002177119,0.00002572599],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004003991,0.0001012843,0.5679157,0.0001646138,0.0003009058,0.001598083,0.0006423729,0.0001278555,0.4027855,0.0001580718,0.0008990719,0.02130262],"study_design_scores_gemma":[0.00002376342,0.000252027,0.9774356,0.00001326752,0.00009077795,0.002745372,0.0002989826,0.0001673673,0.01717778,0.0002110691,0.001575171,0.000008743456],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977778,0.0007340789,0.0003129929,0.00005417528,0.00001107875,0.000005312471,0.0008204165,0.00001301164,0.0002712437],"genre_scores_gemma":[0.9981834,0.0002227854,0.0002614346,0.00006432812,0.0000135897,0.000009014063,0.0007521311,0.000008425557,0.0004849459],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002159627,"threshold_uncertainty_score":0.007224679,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03242996286191731,"score_gpt":0.270181939372722,"score_spread":0.2377519765108047,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}