{"id":"W4319461346","doi":"10.1158/1078-0432.ccr-22-2206","title":"<i>CCNE1</i> and <i>PLK1</i> Mediate Resistance to Palbociclib in HR+/HER2− Metastatic Breast Cancer","year":2023,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"Associazione Italiana per la Ricerca sul Cancro; Università degli Studi di Napoli Federico II; AstraZeneca; Pfizer","keywords":"Palbociclib; Medicine; Capecitabine; Metastatic breast cancer; Oncology; Internal medicine; Breast cancer; Estrogen receptor; Cancer; Cancer research; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.004399402,0.00032263,0.0009831757,0.0003978108,0.0001830675,0.00006134716,0.0004072566,0.0001742334,0.0005978863],"category_scores_gemma":[0.0009689299,0.0002796475,0.0001469982,0.003301746,0.0008216057,0.0001999184,0.0003986589,0.001507742,0.0002932004],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004992488,"about_ca_system_score_gemma":0.0008191423,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001087386,"about_ca_topic_score_gemma":0.007786733,"domain_scores_codex":[0.9943813,0.0006096604,0.001019297,0.001183308,0.001385351,0.00142107],"domain_scores_gemma":[0.9957219,0.00189038,0.0001183338,0.0007702858,0.0005550521,0.0009439967],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.01544174,0.0006582139,0.439079,0.001419323,0.0004964862,0.001175503,0.002042329,0.0001946073,0.004911887,0.0004958056,0.04952458,0.4845605],"study_design_scores_gemma":[0.009796588,0.0004875717,0.7766836,0.002009876,0.0000964972,0.00003736836,0.0009172572,0.0001524265,0.0009301432,0.003677302,0.2045538,0.0006576214],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.914058,0.007714196,0.00002871492,0.07436894,0.0006340201,0.00167983,0.0004203111,0.0002291127,0.0008668872],"genre_scores_gemma":[0.9671118,0.01550526,0.0006805418,0.005665531,0.001295188,0.002041254,0.0000249251,0.000174081,0.007501471],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4839029,"threshold_uncertainty_score":0.9999655,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2179703427293861,"score_gpt":0.5550666118599532,"score_spread":0.3370962691305671,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}