{"id":"W4319593011","doi":"10.1038/s41467-023-36368-5","title":"MORF and MOZ acetyltransferases target unmethylated CpG islands through the winged helix domain","year":2023,"lang":"en","type":"article","venue":"Nature Communications","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"National Institute of General Medical Sciences; National Human Genome Research Institute; National Heart, Lung, and Blood Institute; National Institute on Aging; Japan Society for the Promotion of Science; Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; National Cancer Institute; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"CpG site; Nucleosome; Biology; Genetics; DNA; Computational biology; Gene; Histone; DNA methylation; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007228356,0.0002163554,0.0001784051,0.0001333724,0.0001760099,0.0002154462,0.0001852381,0.0002614093,0.001070683],"category_scores_gemma":[0.0001059261,0.0001410188,0.0002675476,0.00009453921,0.0002172758,0.0001860545,0.0002600778,0.0002401448,0.0003867198],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002969407,"about_ca_system_score_gemma":0.0001383669,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009038747,"about_ca_topic_score_gemma":0.001906976,"domain_scores_codex":[0.999929,0.000005805731,0.000002502523,0.00001706173,0.00002328546,0.00002237219],"domain_scores_gemma":[0.9999427,0.000007041364,0.00001706828,0.000006693334,0.000007241908,0.00001929079],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007543442,0.000006586636,0.001759354,0.00002321731,0.000009434119,0.00007030705,0.00001418001,0.0001503396,0.9945673,0.000304961,0.00004349502,0.002975367],"study_design_scores_gemma":[0.00001411308,0.0001063048,0.02067252,0.000003649686,0.000009381186,0.0006435248,0.00004470207,0.001453831,0.9705994,0.000169508,0.006276118,0.000006919074],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9859132,0.001893142,0.009916993,0.0001417895,0.00001538046,0.00002224788,0.000281481,0.00009538734,0.001720431],"genre_scores_gemma":[0.9922591,0.0005516243,0.004614683,0.00005705089,0.000005571668,0.00001111974,0.0003569806,0.00001330633,0.002130609],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001070683,"threshold_uncertainty_score":0.003581762,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01055415521377851,"score_gpt":0.2737976562755909,"score_spread":0.2632435010618124,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}