{"id":"W4319598375","doi":"10.3390/cells12040536","title":"Prime Editing for Human Gene Therapy: Where Are We Now?","year":2023,"lang":"en","type":"review","venue":"Cells","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Canadian Institutes of Health Research","keywords":"Genome editing; Genetic enhancement; CRISPR; Cas9; Disease; Gene; Computational biology; Medicine; Bioinformatics; Genetics; Biology; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008136546,0.0007589018,0.00100291,0.001085321,0.000312159,0.001304449,0.0008991024,0.001333049,0.0039144],"category_scores_gemma":[0.0007251505,0.0002501791,0.0004485236,0.00119688,0.0007842141,0.002041294,0.0006172194,0.002833355,0.002649796],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007373291,"about_ca_system_score_gemma":0.0010488,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007928178,"about_ca_topic_score_gemma":0.001493199,"domain_scores_codex":[0.9997501,0.0000559068,0.00002406848,0.00003629643,0.0001037368,0.00002997848],"domain_scores_gemma":[0.9996779,0.0001912596,0.00002828921,0.00001402548,0.00005976138,0.00002884863],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005127675,0.00004317383,0.00008814393,0.0103009,0.00004428129,0.0002324415,0.000111052,0.0004101004,0.003775911,0.0174128,0.06075954,0.9067703],"study_design_scores_gemma":[0.0000051552,0.00003216385,0.000100884,0.00124875,0.00002037518,0.0004596082,0.00003451231,0.0000425742,0.0004612209,0.003189688,0.994395,0.00001006717],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00008743009,0.9957274,0.0005231263,0.000898265,0.0004921957,0.000004672515,0.00001706514,0.00001835706,0.002231518],"genre_scores_gemma":[0.0006479124,0.9969163,0.0004744041,0.0005937124,0.000177824,0.000007016077,0.00002593107,0.000004947554,0.001152046],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.0039144,"threshold_uncertainty_score":0.0130949,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04967443153097665,"score_gpt":0.3755295736144998,"score_spread":0.3258551420835231,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}