{"id":"W4319598375","doi":"10.3390/cells12040536","title":"Prime Editing for Human Gene Therapy: Where Are We Now?","year":2023,"lang":"en","type":"review","venue":"Cells","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Canadian Institutes of Health Research","keywords":"Genome editing; Genetic enhancement; CRISPR; Cas9; Disease; Gene; Computational biology; Medicine; Bioinformatics; Genetics; Biology; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001332263,0.0003261334,0.0005844462,0.00005145539,0.00007691518,0.00003162724,0.0002760933,0.0003714568,0.00001691727],"category_scores_gemma":[0.000007462968,0.0002950089,0.0004331108,0.0000778015,0.00002070578,7.65901e-7,0.00009873229,0.0001287662,0.00004906257],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001481451,"about_ca_system_score_gemma":0.00005454437,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001611054,"about_ca_topic_score_gemma":0.0000123686,"domain_scores_codex":[0.9988247,0.00002459069,0.0003126163,0.0004476173,0.000080163,0.0003103008],"domain_scores_gemma":[0.9992718,0.00002156775,0.0001657234,0.0004284222,0.00004299077,0.00006955982],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000005880716,0.00006178419,0.000001919113,0.02472634,0.0006656544,0.00001783089,0.00004019569,0.0000625281,0.09900623,0.00001038128,0.1033914,0.7720099],"study_design_scores_gemma":[0.0001465924,0.00006344148,2.740987e-7,0.001603294,0.00009256803,0.000005555709,0.00001098972,0.000002981397,0.03475136,0.000008762152,0.9630117,0.0003025278],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00002023774,0.9962478,0.002084514,0.00002343284,0.0006430433,0.000670199,0.0001382331,0.0000390002,0.000133597],"genre_scores_gemma":[0.000008140917,0.9905854,0.0003881597,0.00001453782,0.00253593,0.0001745326,0.0004706234,0.0001438419,0.005678872],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8596203,"threshold_uncertainty_score":0.9999502,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04967443153097665,"score_gpt":0.3755295736144998,"score_spread":0.3258551420835231,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}