{"id":"W4319598407","doi":"10.3390/cells12040537","title":"GEF-H1 Transduces FcεRI Signaling in Mast Cells to Activate RhoA and Focal Adhesion Formation during Exocytosis","year":2023,"lang":"en","type":"article","venue":"Cells","topic":"Mast cells and histamine","field":"Immunology and Microbiology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; China Scholarship Council","keywords":"RHOA; Cell biology; Stress fiber; Exocytosis; Degranulation; Syk; Mast cell; Chemistry; Rac GTP-Binding Proteins; Focal adhesion; Signal transduction; Biology; RAC1; Secretion; Receptor; Biochemistry; Immunology; Tyrosine kinase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001892365,0.0001569665,0.0002271422,0.0002568454,0.000153993,0.00002391783,0.0001068399,0.0001614545,0.0003487269],"category_scores_gemma":[0.000005906436,0.0001504401,0.00004732287,0.000255836,0.00004521236,0.0001362449,0.00006311473,0.0001759792,0.0007392746],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003825586,"about_ca_system_score_gemma":0.00001151204,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000565673,"about_ca_topic_score_gemma":0.00004797348,"domain_scores_codex":[0.9989703,0.00007383039,0.0002739719,0.0002739441,0.00003713039,0.0003708025],"domain_scores_gemma":[0.9996727,0.00008008463,0.00005706391,0.0001328474,0.00001861699,0.00003873562],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000123196,0.00003303458,0.00007545471,0.0001164897,0.00001127074,0.00001107082,0.002193995,0.0001882278,0.994019,0.00001359616,0.0003760706,0.002838645],"study_design_scores_gemma":[0.0008184364,0.00008813416,0.002147829,0.00008552056,0.00001203481,0.000005946078,0.0006112424,0.00004531172,0.9860678,0.00001983675,0.009920871,0.0001769761],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982895,0.0002349575,0.00009809939,0.0002186177,0.0003436001,0.0002455266,0.00002233538,0.00007408474,0.0004732259],"genre_scores_gemma":[0.9967189,0.0002425384,0.00007450089,0.00006566381,0.00002986396,0.00001905674,0.00004405245,0.00001823873,0.002787119],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009544801,"threshold_uncertainty_score":0.9502125,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01330713284204761,"score_gpt":0.2135077562826608,"score_spread":0.2002006234406132,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}