{"id":"W4319598453","doi":"10.3390/life13020468","title":"Clinical Biomarker of Sterile Inflammation, HMGB1, in Patients with Chronic Non-Specific Low Back Pain: A Pilot Cross-Sectional Study","year":2023,"lang":"en","type":"article","venue":"Life","topic":"Advanced Glycation End Products research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Memorial Chiropractic College","funders":"Canadian Memorial Chiropractic College; Department of Medicine, University of Toronto; University of Toronto","keywords":"Biomarker; Medicine; Inflammation; Cross-sectional study; HMGB1; Chronic pain; Internal medicine; Pathology; Physical therapy; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009177007,0.00009926678,0.0001305166,0.00008493393,0.00004168487,0.00002027063,0.0001724879,0.00006630384,0.000110072],"category_scores_gemma":[0.000227811,0.00008814807,0.00002576985,0.0003440251,0.000110124,0.00001430979,0.00009877491,0.00009345442,0.00007356046],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002235791,"about_ca_system_score_gemma":0.0001319755,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008099128,"about_ca_topic_score_gemma":0.00004594169,"domain_scores_codex":[0.998485,0.0002167241,0.0004388164,0.000398146,0.0002680961,0.0001931664],"domain_scores_gemma":[0.9990708,0.00003931735,0.0001092957,0.0004291988,0.00027188,0.00007947678],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008337034,0.000429212,0.9896205,0.0000426037,0.00003320909,0.000001028404,0.00003025402,0.0007284843,0.005462537,0.000002256101,0.0005117003,0.002304492],"study_design_scores_gemma":[0.002329835,0.002260596,0.9911037,0.00001004164,8.502691e-7,1.756628e-7,0.00002172817,0.0001311932,0.001091589,0.000006488229,0.002940996,0.0001028035],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987144,0.00002625624,0.0004497837,0.00002805266,0.0001182056,0.0005622962,0.00002063346,0.000009885146,0.00007041542],"genre_scores_gemma":[0.9985888,0.000030408,0.0001484017,0.00002553778,0.0002619893,0.00004868775,0.0004265404,0.00002056212,0.0004490787],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004370948,"threshold_uncertainty_score":0.3594574,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04251002692864236,"score_gpt":0.3534016633646186,"score_spread":0.3108916364359762,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}