{"id":"W4319598453","doi":"10.3390/life13020468","title":"Clinical Biomarker of Sterile Inflammation, HMGB1, in Patients with Chronic Non-Specific Low Back Pain: A Pilot Cross-Sectional Study","year":2023,"lang":"en","type":"article","venue":"Life","topic":"Advanced Glycation End Products research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Memorial Chiropractic College","funders":"Canadian Memorial Chiropractic College; Department of Medicine, University of Toronto; University of Toronto","keywords":"Biomarker; Medicine; Inflammation; Cross-sectional study; HMGB1; Chronic pain; Internal medicine; Pathology; Physical therapy; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004549658,0.000290374,0.0003476667,0.0003552779,0.0003860312,0.0004032572,0.0001173831,0.0004277293,0.001251485],"category_scores_gemma":[0.0007510894,0.0002177335,0.0002337557,0.0003058387,0.0002047494,0.0002906293,0.000229147,0.0003528681,0.0002656724],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009238386,"about_ca_system_score_gemma":0.0001226393,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005611855,"about_ca_topic_score_gemma":0.0006996888,"domain_scores_codex":[0.9997435,0.00008895938,0.00002642365,0.00006654114,0.00004000982,0.00003446865],"domain_scores_gemma":[0.9995881,0.00008078636,0.0001253049,0.00003103817,0.0000809535,0.00009385083],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004582493,0.0002468071,0.9955257,0.00003610337,0.00005031225,0.0001377908,0.0002121251,0.00001220376,0.001924475,0.00001224185,0.00004240544,0.00134167],"study_design_scores_gemma":[0.00002836895,0.001896326,0.9966066,0.000006579158,0.00006237555,0.0006700163,0.0002591979,0.00007937315,0.0001594624,0.00001331127,0.0002148025,0.000003537292],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992817,0.000276327,0.0001278547,0.00001189901,0.000005093179,0.00002338393,0.00008047221,0.000001422677,0.000191821],"genre_scores_gemma":[0.9994591,0.00009083391,0.0001335323,0.00003423627,0.00001258184,0.00002266371,0.0001051656,6.915421e-7,0.0001412344],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001251485,"threshold_uncertainty_score":0.00418663,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04251002692864236,"score_gpt":0.3534016633646186,"score_spread":0.3108916364359762,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}