{"id":"W4319598540","doi":"10.3390/cells12040534","title":"Opportunities and Challenges for the Development of MRCK Kinases Inhibitors as Potential Cancer Chemotherapeutics","year":2023,"lang":"en","type":"review","venue":"Cells","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Metropolitan University","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Canadian Cancer Society","keywords":"Biology; Cell biology; Kinase; CDC42; Phosphorylation; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001251443,0.0009545238,0.001771709,0.002112463,0.0003701684,0.001621155,0.001283348,0.001828196,0.005723763],"category_scores_gemma":[0.001114629,0.0003913497,0.000751802,0.001535327,0.0009975396,0.002680376,0.001046904,0.004917893,0.003461303],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001124371,"about_ca_system_score_gemma":0.001214025,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008021119,"about_ca_topic_score_gemma":0.002374968,"domain_scores_codex":[0.9997118,0.00007113377,0.00003097488,0.00004398414,0.0001036811,0.00003842304],"domain_scores_gemma":[0.9993933,0.0002994201,0.00005610056,0.00002456679,0.0001581958,0.00006828873],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001448862,0.0001802608,0.0001264705,0.01075385,0.00009101084,0.0003429787,0.00009128283,0.0008943061,0.0031069,0.0205657,0.07199829,0.8917041],"study_design_scores_gemma":[0.00003325823,0.0001009555,0.0002592746,0.001545064,0.0000429087,0.0005015266,0.00004015564,0.0001235491,0.0003308152,0.004338292,0.9926682,0.00001612325],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001193517,0.9967647,0.0002321531,0.001008521,0.0003602285,0.000005635063,0.0000197907,0.00001694046,0.001472829],"genre_scores_gemma":[0.0007482196,0.9969286,0.000328179,0.0006663446,0.0003456344,0.00001327718,0.00003394486,0.000003767276,0.0009319828],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.005723763,"threshold_uncertainty_score":0.01914793,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.138813972183925,"score_gpt":0.3362898652031839,"score_spread":0.1974758930192589,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}