{"id":"W4319598541","doi":"10.3390/biom13020318","title":"Restoring Epigenetic Reprogramming with Diet and Exercise to Improve Health-Related Metabolic Diseases","year":2023,"lang":"en","type":"review","venue":"Biomolecules","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Kingston Health Sciences Centre; Queen's University","funders":"Natural Sciences and Engineering Research Council of Canada; Harvard Stem Cell Institute","keywords":"Epigenetics; Reprogramming; Epigenome; Disease; Biology; Bioinformatics; DNA methylation; Medicine; Genetics; Cell; Internal medicine; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004504725,0.0007352004,0.0009609226,0.001638326,0.0002451071,0.0008120411,0.0006765111,0.001063456,0.004663153],"category_scores_gemma":[0.0005520823,0.0001995586,0.0004253192,0.001203793,0.0004072317,0.0008481999,0.0007404841,0.001517486,0.002334756],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005315679,"about_ca_system_score_gemma":0.0006791429,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007518951,"about_ca_topic_score_gemma":0.001403708,"domain_scores_codex":[0.9998742,0.00002272937,0.00001487086,0.00002858258,0.00004311336,0.0000164306],"domain_scores_gemma":[0.9998354,0.00007398707,0.00001896329,0.000007167499,0.00004743135,0.00001706812],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007661,0.00008369442,0.0001481675,0.01155665,0.00009546996,0.0001933711,0.00005571482,0.0003655022,0.004552179,0.007318632,0.02237151,0.9531825],"study_design_scores_gemma":[0.00001315353,0.00008593131,0.0005973291,0.001707291,0.0000786814,0.000705499,0.00003875876,0.0001145354,0.001617076,0.002762527,0.9922615,0.00001770793],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001913056,0.9970412,0.0003582284,0.0004010512,0.0003298135,0.00000686337,0.00002837066,0.00001377151,0.001629436],"genre_scores_gemma":[0.00129085,0.9964474,0.0003937569,0.0002432037,0.0001923522,0.00001256091,0.00004711482,0.000003858144,0.001368835],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004663153,"threshold_uncertainty_score":0.01559973,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03251803898532635,"score_gpt":0.3343410853873497,"score_spread":0.3018230464020234,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}