{"id":"W4319599833","doi":"10.3390/v15020465","title":"Specialized DNA Structures Act as Genomic Beacons for Integration by Evolutionarily Diverse Retroviruses","year":2023,"lang":"en","type":"review","venue":"Viruses","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health; Canada Research Chairs","keywords":"Provirus; Biology; Genome; Genetics; Integrase; DNA; Computational biology; Virology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001034644,0.0003972179,0.0006188512,0.0001171884,0.0001177947,0.00005591282,0.0002973967,0.0004164847,0.0000461184],"category_scores_gemma":[0.0003340205,0.0003534195,0.0004185289,0.0001181819,0.00006091627,0.000004617327,0.0001310312,0.0001356652,0.00006287254],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006225943,"about_ca_system_score_gemma":0.0001808104,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007075672,"about_ca_topic_score_gemma":0.00006609126,"domain_scores_codex":[0.9986429,0.00004985675,0.0003902086,0.0005072802,0.0001235231,0.000286199],"domain_scores_gemma":[0.9992426,0.00007906571,0.0001722039,0.0003730572,0.00005108485,0.00008198617],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001340368,0.00006379645,0.00001666922,0.004273425,0.001230325,0.000005829121,0.00006038765,0.00004260469,0.1166524,0.0006309537,0.3018878,0.5750018],"study_design_scores_gemma":[0.0002219046,0.00012005,0.00001045534,0.0003480707,0.0003532342,0.000007698936,0.00002415356,0.000002043742,0.006857799,0.00009715829,0.9915756,0.0003818127],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0006561435,0.9939634,0.002013411,0.000008248459,0.000764026,0.0008234763,0.001610325,0.00006417224,0.00009674799],"genre_scores_gemma":[0.0001246232,0.9953014,0.000452738,0.0001340903,0.001068707,0.0001637938,0.002014238,0.0001092118,0.0006312068],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.6896878,"threshold_uncertainty_score":0.9998918,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05102377658246852,"score_gpt":0.3853434292747491,"score_spread":0.3343196526922805,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}