{"id":"W4319600651","doi":"10.3390/jcm12041313","title":"miR-199a-5p Reduces Chondrocyte Hypertrophy and Attenuates Osteoarthritis Progression via the Indian Hedgehog Signal Pathway","year":2023,"lang":"en","type":"article","venue":"Journal of Clinical Medicine","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"Key Science and Technology Program of Shaanxi Province; Natural Science Foundation of Shaanxi Province; National Natural Science Foundation of China; Honghui Hospital","keywords":"Indian hedgehog; Medicine; Osteoarthritis; Chondrocyte; Endochondral ossification; Cartilage; Hedgehog signaling pathway; Signal transduction; Cell biology; Internal medicine; Endocrinology; Cancer research; Pathology; Anatomy; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001282949,0.0003534809,0.0005182684,0.0003569982,0.000219034,0.0002936364,0.0002581203,0.0003358675,0.001329963],"category_scores_gemma":[0.0001796355,0.0001691965,0.0003935148,0.0001659559,0.0002888209,0.0002295457,0.0002256529,0.001006932,0.0002638615],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000193678,"about_ca_system_score_gemma":0.0004810881,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007756519,"about_ca_topic_score_gemma":0.001339263,"domain_scores_codex":[0.9998409,0.00002666907,0.00001926232,0.00001844459,0.00006067539,0.00003401479],"domain_scores_gemma":[0.9999444,0.000007904384,0.00001381775,0.00000436838,0.00001089725,0.00001865161],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002677463,0.0007344116,0.0004582062,0.0004909583,0.00006591638,0.0001230664,0.00004328913,0.0001457241,0.9792138,0.0002758586,0.0007165751,0.01505475],"study_design_scores_gemma":[0.00140686,0.008030425,0.01878556,0.00005816868,0.0004117632,0.0006880863,0.0001638491,0.003701376,0.9443467,0.0004741076,0.02189211,0.00004097462],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9721214,0.01599914,0.004053092,0.000643805,0.0004743473,0.0001677818,0.0005780492,0.0004387943,0.005523534],"genre_scores_gemma":[0.9888649,0.004727877,0.002037534,0.0003657814,0.00007314525,0.0001559591,0.0005417548,0.00002943584,0.0032037],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001329963,"threshold_uncertainty_score":0.004449129,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04416469328679151,"score_gpt":0.3653681551720344,"score_spread":0.3212034618852429,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}